Eriodictyol-Amplified 67-kDa Laminin Receptor Signaling Potentiates the Antiallergic Effect of O-Methylated Catechin.

Journal of Natural Products
Yoshinori FujimuraHirofumi Tachibana

Abstract

(-)-Epigallocatechin-3-O-(3-O-methyl) gallate (1, EGCG3″Me), an antiallergic O-methylated catechin, is present in high quantities in the green tea cultivar "Benifuuki" (Camellia sinensis L.). Previous studies have shown that EGCG3″Me inhibited basophil degranulation mediated through the cell-surface 67-kDa laminin receptor (67LR), but the mechanisms are not fully elucidated. This study aimed to investigate the mechanisms underlying the inhibitory effect of EGCG3″Me on IgE/antigen (Ag)-mediated degranulation and the combined effect of EGCG3″Me with eriodictyol (2), a bioactive flavanone. EGCG3″Me inhibited β-hexosaminidase release from the rat basophilic/mast cell line RBL-2H3 stimulated by IgE/Ag and induced acid sphingomyelinase (ASM) activity. This induction was inhibited by anti-67LR antibody treatment. The ASM-specific inhibitor desipramine inhibited EGCG3″Me-induced suppression of degranulation. The soluble guanylate cyclase (sGC) inhibitor NS2028 weakened the potency of EGCG3″Me, and the sGC activator BAY41-2272 suppressed degranulation. The ability of EGCG3″Me to induce ASM activity and inhibit degranulation was amplified by eriodictyol. Furthermore, oral administration of the lemon-peel-derived eriodyctiol-7-O-glucoside...Continue Reading

References

Feb 1, 1992·Immunological Reviews·H Metzger
Mar 29, 2000·Bioscience, Biotechnology, and Biochemistry·H TachibanaK Yamada
Jul 11, 2000·The Journal of Allergy and Clinical Immunology·M KotaniT Tanaka
Mar 17, 2004·Nature Structural & Molecular Biology·Hirofumi TachibanaKoji Yamada
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mari Maeda-YamamotoToshiaki Kawakami
Sep 6, 2005·Biochemical and Biophysical Research Communications·Yoshinori FujimuraHirofumi Tachibana
Feb 14, 2006·Nature Reviews. Immunology·Alasdair M Gilfillan, Christine Tkaczyk
Oct 12, 2007·Biochemical and Biophysical Research Communications·Yoshinori FujimuraHirofumi Tachibana
Dec 15, 2007·The Journal of Biological Chemistry·Daisuke UmedaHirofumi Tachibana
Mar 25, 2008·Archives of Biochemistry and Biophysics·Yoshinori FujimuraHirofumi Tachibana
May 28, 2009·Nature Reviews. Cancer·Chung S YangSonia C Picinich
Jun 23, 2009·Allergology International : Official Journal of the Japanese Society of Allergology·Mari Maeda-YamamotoTakao Fujisawa
Jun 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eui Hong ByunHirofumi Tachibana
Aug 20, 2011·PloS One·Yoshinori FujimuraHirofumi Tachibana
Jun 6, 2012·PloS One·Yoshinori FujimuraHirofumi Tachibana
Jul 13, 2012·Bioscience, Biotechnology, and Biochemistry·Jung-Min YooTack-Joong Kim
Jan 26, 2013·The Journal of Clinical Investigation·Motofumi KumazoeHirofumi Tachibana
Feb 25, 2014·Allergology International : Official Journal of the Japanese Society of Allergology·Sawako MasudaTakao Fujisawa
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·Khizar HayatSobia Mushtaq
Dec 17, 2014·The Journal of Allergy and Clinical Immunology·Zuyi WengTheoharis C Theoharides
Jan 13, 2017·Chemical Communications : Chem Comm·Yuhui HuangHirofumi Tachibana
Mar 6, 2018·Bioscience, Biotechnology, and Biochemistry·Kaeko MurotaMariko Uehara
Mar 14, 2019·International Journal of Molecular Sciences·Eun-Young Kwon, Myung-Sook Choi
May 8, 2019·Journal of Nutritional Science and Vitaminology·Tomoko KamoharaYukari Egashira
Oct 6, 2019·Biochemical and Biophysical Research Communications·Jaehoon BaeHirofumi Tachibana
Mar 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yi XuHui-Li Wang
Mar 17, 2020·Biochemical and Biophysical Research Communications·Motofumi KumazoeHirofumi Tachibana

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