Eriodictyol Inhibits Proliferation, Metastasis and Induces Apoptosis of Glioma Cells via PI3K/Akt/NF-κB Signaling Pathway

Frontiers in Pharmacology
Wenjun LiSongqing Liu

Abstract

Glioma is the most common type of malignant brain tumor. Due to its highly aggressive and metastatic features, glioma is associated with poor prognosis and a lack of effective treatments. Eriodictyol, a natural flavonoid compound, has been reported to possess anti-inflammatory and antioxidant effects. However, the anti-tumor effects of eriodictyol and the underlying mechanisms have rarely been reported. In this study, we found that eriodictyol has anti-tumor activity in lung, colon, breast, pancreas, and liver cancer, and most significantly in glioma cell lines. Eriodictyol dose- and time-dependently suppresses cell proliferation, migration, and invasion in U87MG and CHG-5 glioma cells. In addition, eriodictyol induces apoptosis in U87MG and CHG-5 cells, as evaluated by flow cytometry, immunofluorescence, and Western blot. Furthermore, eriodictyol downregulates the phosphoinositide 3-kinase (PI3K)/Akt/NF-κB signaling pathway in a concentration-dependent manner. Moreover, the effects of eriodictyol on the apoptosis of glioma cells are enhanced by LY294002 (a PI3K inhibitor) and reversed by 740 Y-P (a PI3K agonist). In a mouse xenograft model, eriodictyol not only dramatically suppressed tumor growth but also induced apoptosis in...Continue Reading

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Citations

Jun 12, 2020·Cancers·Alena LiskovaPeter Kubatka
Aug 22, 2020·Journal of Clinical Laboratory Analysis·Guang-Zhang LiZhi-Xin Liu
Dec 4, 2020·Technology in Cancer Research & Treatment·Jingtao WangXiushan Li
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Jun 8, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yating GaoZegeng Li

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Methods Mentioned

BETA
xenograft
fluorescence microscopy
Assay
electrophoresis
PCR
flow cytometry

Software Mentioned

GraphPad
Image J

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