ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors.

Cell Communication and Signaling : CCS
Min Song, Stacey D Finley

Abstract

Angiogenesis plays an important role in the survival of tissues, as blood vessels provide oxygen and nutrients required by the resident cells. Thus, targeting angiogenesis is a prominent strategy in many different settings, including both tissue engineering and cancer treatment. However, not all of the approaches that modulate angiogenesis lead to successful outcomes. Angiogenesis-based therapies primarily target pro-angiogenic factors such as vascular endothelial growth factor-A (VEGF) or fibroblast growth factor (FGF) in isolation, and there is a limited understanding of how these promoters combine together to stimulate angiogenesis. Targeting one pathway could be insufficient, as alternative pathways may compensate, diminishing the overall effect of the treatment strategy. To gain mechanistic insight and identify novel therapeutic strategies, we have developed a detailed mathematical model to quantitatively characterize the crosstalk of FGF and VEGF intracellular signaling. The model focuses on FGF- and VEGF-induced mitogen-activated protein kinase (MAPK) signaling to promote cell proliferation and the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway, which promotes cell survival and migration. We fit the mo...Continue Reading

References

Jan 1, 1990·Progress in Growth Factor Research·W Risau
Oct 1, 1989·Journal of Applied Physiology·D B RubinK D Bauer
Aug 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A RatajskaR J Tomanek
Oct 3, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R PaderaR Sasisekharan
Nov 27, 1999·Science·S Zimmermann, K Moelling
Jan 9, 2001·The Journal of Investigative Dermatology. Symposium Proceedings·M G TonnesenR A Clark
Apr 3, 2001·Trends in Pharmacological Sciences·M J Cross, L Claesson-Welsh
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Ayako NakashioTakashi Tsuruo
Jun 6, 2002·The Journal of Biological Chemistry·Karin MoellingMarc Schweneker
Jun 29, 2002·Circulation Research·Ichiro Shiojima, Kenneth Walsh
Jan 29, 2003·The Journal of Biological Chemistry·Kevin C CorbitMarsha Rich Rosner
Mar 19, 2003·Circulation·Timothy D HenryUNKNOWN VIVA Investigators
Apr 26, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Feilim Mac Gabhann, Aleksander S Popel
Jul 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yuko KawakamiToshiaki Kawakami
Sep 11, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Marek ZygmuntOlin D Liang
Dec 13, 2003·The Journal of Biological Chemistry·Jennifer A ClarkJennifer D Black
Jun 3, 2004·Annals of Biomedical Engineering·Renee J Filion, Aleksander S Popel
May 9, 2008·The New England Journal of Medicine·Robert S Kerbel
Jun 24, 2008·Journal of Theoretical Biology·Simeone MarinoDenise E Kirschner
Oct 22, 2008·Molecular and Cellular Biology·Catherine ChabotIsabelle Royal
Jun 6, 2009·Tissue Engineering. Part B, Reviews·Michael LovettDavid L Kaplan
Jul 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Klaus P HoeflichMark R Lackner
Nov 4, 2009·Traffic·Alexander F BrunsSreenivasan Ponnambalam
Jan 12, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Areck A UcuzianHoward P Greisler
Feb 23, 2010·Journal of Atherosclerosis and Thrombosis·Christopher SchneeweisStephan Goetze
Nov 10, 2010·PLoS Computational Biology·Bing ZhaoMichael Fannon
Jul 5, 2012·Cold Spring Harbor Perspectives in Medicine·Sina Koch, Lena Claesson-Welsh

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Citations

Mar 2, 2021·Pathology, Research and Practice·Zhi Xiong ChongWan Yong Ho
Jun 3, 2021·International Journal of Molecular Sciences·Dilara Z GatinaIlnur I Salafutdinov
Jul 10, 2021·Frontiers in Cell and Developmental Biology·Bo LiYi Men

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