Abstract
Acute lung injury (ALI) is one of several complications in patients with traumatic brain injury (TBI). Autophagy is a primary homeostatic process that promotes cell survival under stress. Accumulating evidence implicates autophagy in the pathogenesis of ALI under various conditions. However, the role of autophagy in TBI-induced ALI remains unknown. The aim of this study was to adjust autophagy with pharmacological agents to determine its functional significance in TBI-induced ALI. Rats were preconditioned with autophagy promoter rapamycin or inhibitor 3-methyladenine before they were challenged with TBI. Extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor U0126, mechanistic target of rapamycin (mTOR) inhibitor rapamycin, and signal transducer and activator of transcription 3 (Stat3) inhibitor S31-201 were used to test the role of ERK1/2/mTOR/Stat3 signaling pathway in regulating autophagy. Autophagy is activated in lung tissues after TBI. Enhancement of autophagy suppressed apoptosis, inflammation and oxidative stress in lung tissues, which were activated after TBI, whereas inhibition of autophagy aggravated these critical pathological changes. Autophagy also improved TBI-induced impairment in pulmonary barrier functio...Continue Reading
Citations
Oct 27, 2018·Toxicology and Industrial Health·Qiu-Ping LiuShi-Jie Wang
Mar 21, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Qing-Chun LiZhen-Bo Su
Dec 17, 2019·Journal of Cellular and Molecular Medicine·Fangfang WuDaqing Chen
Sep 13, 2019·Journal of Cellular Physiology·Zhiqing ZengHongtao Qu
Dec 12, 2018·Journal of Cellular Biochemistry·Lei ZhangXiaojing Dong
Dec 18, 2020·Frontiers in Cellular Neuroscience·Peter SolárMarek Joukal
Dec 5, 2020·Life Sciences·Wei PengFen Liu
Nov 15, 2019·Respiratory Physiology & Neurobiology·Hongshu SuiChanglong Xu
May 29, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lei LiZhaowei Zhang
Jul 6, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jianbo YangXinying Wang
Nov 4, 2020·Cells·Nafiseh Chalabi Hagkarim, Roger J Grand
Jan 6, 2021·Journal of Cell Communication and Signaling·Rohollah NikooieSamira Zand
Aug 24, 2020·Life Sciences·Selvaraj VishnupriyaRajan Radha Rasmi
Jun 3, 2021·International Journal of Molecular Sciences·Jinglong ChenXiaojing Yang
Jun 12, 2021·Journal of Cellular and Molecular Medicine·Jun LiJiangzhou Peng
Aug 15, 2021·Neurochemistry International·Yi WangChunhua Liu
Jan 18, 2022·Cellular and Molecular Neurobiology·Mohammad Rafi KhezriMorteza Ghasemnejad-Berenji