Erlotinib as Neoadjuvant Therapy in Stage IIIA (N2) EGFR Mutation-Positive Non-Small Cell Lung Cancer: A Prospective, Single-Arm, Phase II Study

The Oncologist
Liwen XiongBaohui Han

Abstract

The findings of this prospective, single-arm, phase II study showed that neoadjuvant erlotinib was well tolerated and might improve the radical resection rate in patients with stage IIIA-N2 epidermal growth factor receptor mutation-positive non-small cell lung cancer (NSCLC).Erlotinib shows promise as a neoadjuvant therapy option in this patient population.Next-generation sequencing may be useful for predicting outcomes with preoperative tyrosine kinase inhibitors (TKIs) in patients with NSCLC.Large-scale randomized controlled trials investigating the role of TKIs in perioperative therapy, combining neoadjuvant and adjuvant treatments to enhance personalized therapy for patients in this precision medicine era, are warranted. Information on epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) as neoadjuvant therapy in non-small cell lung cancer (NSCLC) is scarce. We evaluated whether neoadjuvant erlotinib improves operability and survival in patients with stage IIIA-N2 EGFR mutation-positive NSCLC. We conducted a prospective, single-arm, phase II study. Patients received erlotinib 150 mg per day for 56 days in the neoadjuvant period. The primary endpoint was the radical resection rate. Nineteen patients were...Continue Reading

References

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Feb 18, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jae Myoung NohJong-Mu Sun

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Citations

Sep 16, 2018·Nature Reviews. Clinical Oncology·Peter Sidaway
Dec 31, 2019·The Journal of International Medical Research·Liwen XiongBaohui Han
Jun 14, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wen-Zhao ZhongYi-Long Wu
Sep 4, 2020·International Journal of Molecular Sciences·Alex FriedlaenderChristian D Rolfo
Nov 10, 2020·Current Opinion in Oncology·Juejun Gong, Li Zhang
Apr 29, 2020·The Journal of Thoracic and Cardiovascular Surgery·Yang ZhangHaiquan Chen
Apr 25, 2021·Journal of Medical Case Reports·Caroline Y ChenDaniel Sanghoon Shin
Feb 1, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisYasushi Yatabe
Jun 3, 2021·Cancers·Toon AllaeysPaul E Van Schil
Jul 6, 2021·Frontiers in Oncology·Yiming ZhaoBaohui Han
Jan 6, 2022·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aaron C Tan, Daniel S W Tan

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Methods Mentioned

BETA
surgical resection
PCR
DNA assay

Clinical Trials Mentioned

NCT01217619

Software Mentioned

VarScan
SAS
Tophat2
MuTect
BurlistItemPairs Aligner
Genome Analysis Toolkit
Factera

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