Erlotinib-cisplatin combination inhibits growth and angiogenesis through c-MYC and HIF-1α in EGFR-mutated lung cancer in vitro and in vivo

Neoplasia : an International Journal for Oncology Research
Jasmine G Lee, Reen Wu

Abstract

Combination treatment for non-small cell lung cancer (NSCLC) is becoming more popular due to the anticipation that it may be more effective than single drug treatment. In addition, there are efforts to genetically screen patients for specific mutations in light of attempting to administer specific anticancer agents that are most effective. In this study, we evaluate the anticancer and anti-angiogenic effects of low dose erlotinib-cisplatin combination in NSCLC in vitro and in vivo. In NSCLC cells harboring epidermal growth factor receptor (EGFR) mutations, combination erlotinib-cisplatin treatment led to synergistic cell death, but there was minimal efficacy in NSCLC cells with wild-type EGFR. In xenograft models, combination treatment also demonstrated greater inhibition of tumor growth compared to individual treatment. The anti-tumor effect observed was secondary to the targeting of angiogenesis, evidenced by decreased vascular endothelial growth factor (VEGF) levels and decreased levels of CD31 and microvessel density. Combination treatment targets angiogenesis through down-regulation of the c-MYC/hypoxia inducible factor 1-alpha (HIF-1α) pathway. In fact, cell lines with EGFR exon 19 deletions expressed high basal levels of...Continue Reading

References

May 29, 1998·Journal of Molecular and Cellular Cardiology·B K Slinker
Jul 29, 2003·Journal of Pharmaceutical Sciences·Evelyn D Lobo, Joseph P Balthasar
Jun 19, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L CastilloG Milano
Aug 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·William PaoHarold Varmus
Feb 25, 2005·The New England Journal of Medicine·Susumu KobayashiBalázs Halmos
May 12, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstAlan Sandler
May 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eunice L KwakDaniel A Haber
Jul 15, 2005·The New England Journal of Medicine·Frances A ShepherdUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jul 18, 2006·Critical Reviews in Oncology/hematology·C GridelliP Maione
Sep 8, 2006·The New England Journal of Medicine·Ken A OlaussenUNKNOWN IALT Bio Investigators
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fred R HirschBrian Holloway
Jan 20, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yonatan Y MahllerTimothy P Cripe
Feb 24, 2007·Nature Reviews. Cancer·Sreenath V SharmaDaniel A Haber
May 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Floriana MorgilloHo-Young Lee
Dec 7, 2007·International Journal of Radiation Biology·H Peter RodemannMahmoud Toulany
Jan 29, 2008·Recent Patents on Anti-cancer Drug Discovery·Markus Galanski
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Henk M W VerheulRoberto Pili
Jul 23, 2008·International Journal of Medical Sciences·Xiaozhu Zhang, Alex Chang
Sep 10, 2008·Current Oncology Reports·Ranjit K Goudar, Gordana Vlahovic
Feb 4, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takafumi OkabeKazuhiko Nakagawa
Aug 13, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Haiyan LuEdward L Schwartz
Aug 21, 2009·The New England Journal of Medicine·Rafael RosellUNKNOWN Spanish Lung Cancer Group
Aug 28, 2009·Expert Reviews in Molecular Medicine·Evon PoonMargaret Ashcroft
Jan 26, 2010·International Journal of Experimental Pathology·Fang-Zhen ShenYan-Tao Wang
Mar 10, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Caroline H DiepHaiyong Han
Jun 21, 2011·Journal of Biomedicine & Biotechnology·Takayuki KosakaHiroyuki Kuwano
Jul 22, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Geoffrey R OxnardWilliam Pao
Sep 6, 2011·Oncogene·L GalluzziG Kroemer
Dec 3, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kenichi SudaTetsuya Mitsudomi
Dec 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Qian XieGeorge F Vande Woude
Jan 31, 2012·The Lancet Oncology·Rafael RosellUNKNOWN Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia T
Jul 4, 2012·Nature Genetics·Zhenfeng ZhangTrever G Bivona
Dec 15, 2012·Molecular Cancer Research : MCR·Daisuke MinamiKatsuyuki Kiura
Mar 20, 2013·BMC Cancer·Agnès FiguerasGabriel Capellà

❮ Previous
Next ❯

Citations

Aug 15, 2015·Cancer Letters·Yu Sun
Nov 5, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Ivayla ApostolovaThomas Kalinski
Oct 16, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yaming DuDaohan Sun
Aug 28, 2019·Oncology Letters·Roman C BrandsUrs D A Müller-Richter
Jun 20, 2017·International Journal of Oncology·Chinami MasudaKaname Yamamoto
Nov 2, 2019·Dose-response : a Publication of International Hormesis Society·Wei SunTiefeng Ji
Mar 19, 2021·Frontiers in Cell and Developmental Biology·Peijie WuNa Xie
Dec 26, 2017·Cell Chemical Biology·Yang GaoRani E George
Jul 25, 2021·Cancers·Julien AncelValérian Dormoy
Nov 28, 2020·Current Topics in Medicinal Chemistry·Tiziano Marzo, Diego La Mendola

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
Assay

Software Mentioned

ImageJ
Prism

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.