Error in measurement of oxygen and carbon dioxide concentrations by the DeltatracII metabolic monitor in the presence of desflurane

British Journal of Anaesthesia
T W ScheerenJ O Arndt

Abstract

In experiments in dogs on the metabolic effects of inhalation anaesthetics, we noticed that in the presence of desflurane, oxygen uptake (VO2) measured with the Deltatracll metabolic monitor seemingly increased whereas it decreased when determined independently by the Fick principle. This difference remained even after correction for changes in gas concentration on addition of an inhalation anaesthetic. Therefore, we suspected that desflurane interferes with the measurement of gas concentrations. Using different precision gases, we found that desflurane disturbed both the paramagnetic oxygen sensor and the infrared carbon dioxide detector so that the measured oxygen (when FIO2 was > 0.21) and carbon dioxide concentrations were greater than expected. These errors multiply in the computing process of oxygen uptake by the DeltatracII. When the DeltatracII is to be used during inhalation anaesthesia, its results should be corrected for the presence of an anaesthetic gas. More importantly, corrections must also be made for measurement errors of the oxygen and carbon dioxide sensors, unless the device has been equipped with a modified (nickel membrane) oxygen sensor insensitive to the presence of volatile agents.

Citations

Oct 4, 2011·American Journal of Veterinary Research·Tamas D Ambrisko, Alan M Klide

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.