journal cover

Error-prone DNA polymerase and oxidative stress increase the incidences of A to G mutations in tumors

Oncotarget

Jun 6, 2017

Jiannan Lin, Tieliu Shi

Abstract

Mutational processes for A→G mutations in tumors are not well understood. To uncover the mutational mechanisms, we analyzed molecular profiles of more than 9,000 tumor samples from The Cancer Genome Atlas (TCGA). The present study found that error-prone DNA polymerases were involved in ...read more

Mentioned in this Paper

Study
Genome
ras Oncogene
Energy Metabolism
Neoplasms
Oxidative Stress
Gene Mutation
Oxidative Stress Analysis
Kidney Neoplasm
Stomach Neoplasms
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

Hormone-Related Cancers

This feed focuses on hormone-related cancers including cancer of the breast, endometrium, ovary, prostate, testis, thyroid, and bone, all of which share unique mechanisms of carcinogenesis. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Inflammation & Cancer

Inflammation has been implicated in initiation and progression of tumors, as well as elimination of cancerous cells. Here is the latest research on the role of inflammation in cancer.

Related Papers

Cancer Discovery

From TCGA to treatment

Cancer DiscoveryDecember 12, 2012
Chemical Reviews

Mechanisms of DNA polymerases

Chemical ReviewsJune 6, 2009
Anthony J Berdis
© 2020 Meta ULC. All rights reserved

Error-prone DNA polymerase and oxidative stress increase the incidences of A to G mutations in tumors

Oncotarget

Jun 6, 2017

Jiannan Lin, Tieliu Shi

PMID: 28582771

DOI: 10.18632/oncotarget.13293

Abstract

Mutational processes for A→G mutations in tumors are not well understood. To uncover the mutational mechanisms, we analyzed molecular profiles of more than 9,000 tumor samples from The Cancer Genome Atlas (TCGA). The present study found that error-prone DNA polymerases were involved in ...read more

Mentioned in this Paper

Study
Genome
ras Oncogene
Energy Metabolism
Neoplasms
Oxidative Stress
Gene Mutation
Oxidative Stress Analysis
Kidney Neoplasm
Stomach Neoplasms

Similar Papers Found In These Feeds

Hormone-Related Cancers

This feed focuses on hormone-related cancers including cancer of the breast, endometrium, ovary, prostate, testis, thyroid, and bone, all of which share unique mechanisms of carcinogenesis. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Cancer Discovery

From TCGA to treatment

Cancer DiscoveryDecember 12, 2012
Chemical Reviews

Mechanisms of DNA polymerases

Chemical ReviewsJune 6, 2009
Anthony J Berdis
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
/papers/error-prone-dna-polymerase-and-oxidative-stress/28582771