Jun 6, 2017

Error-prone DNA polymerase and oxidative stress increase the incidences of A to G mutations in tumors

Oncotarget
Jiannan Lin, Tieliu Shi

Abstract

Mutational processes for A→G mutations in tumors are not well understood. To uncover the mutational mechanisms, we analyzed molecular profiles of more than 9,000 tumor samples from The Cancer Genome Atlas (TCGA). The present study found that error-prone DNA polymerases were involved in stomach tumors with high fraction of A→G mutations. High levels of apoptosis in kidney cancers and high levels of energy metabolism in thyroid cancers increased A→G mutation rate, which was associated with high oxidative stress. We also found that the frequencies of RAS gene mutations were increased in thyroid cancers with high level of energy metabolism because of high-frequency A→G mutations.

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Mentioned in this Paper

Study
Genome
ras Oncogene
Energy Metabolism
Neoplasms
Oxidative Stress
Gene Mutation
Oxidative Stress Analysis
Kidney Neoplasm
Stomach Neoplasms

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