Error-prone polymerase, DNA polymerase IV, is responsible for transient hypermutation during adaptive mutation in Escherichia coli.

Journal of Bacteriology
Joshua D TompkinsP L Foster

Abstract

The frequencies of nonselected mutations among adaptive Lac(+) revertants of Escherichia coli strains with and without the error-prone DNA polymerase IV (Pol IV) were compared. This frequency was more than sevenfold lower in the Pol IV-defective strain than in the wild-type strain. Thus, the mutations that occur during hypermutation are due to Pol IV.

References

Feb 1, 1992·Molecular & General Genetics : MGG·L Boe
Aug 1, 1991·Genetics·J Cairns, P L Foster
Sep 8, 1988·Nature·J CairnsS Miller
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·P L FosterM F Goodman
Apr 21, 1995·Science·J P RadicellaM S Fox
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·P L Foster, J M Trimarchi
Jul 15, 1994·Science·S M RosenbergR S Harris
Apr 8, 1994·Science·R S HarrisS M Rosenberg
Jan 1, 1993·Annual Review of Microbiology·P L Foster
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·W A Rosche, P L Foster
Mar 20, 2001·Nature Reviews. Molecular Cell Biology·M F Goodman, B Tippin
Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Heather HendricksonJohn R Roth
May 23, 2003·Cold Spring Harbor Symposia on Quantitative Biology·P L Foster

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Citations

Aug 19, 2008·Applied and Environmental Microbiology·Manfredo J SeufferheldMaria E Farias
Oct 26, 2010·Journal of Bacteriology·Bernardo N DeboraMario Pedraza-Reyes
Sep 19, 2006·Journal of Bacteriology·Wojciech KubanIwona J Fijalkowska
Jan 9, 2007·Journal of Bacteriology·Jeffrey D StumpfPatricia L Foster
Jun 2, 2009·Journal of Bacteriology·Brenna W ShurtleffPenny J Beuning
Jul 3, 2004·Journal of Bacteriology·Wojciech KubanIwona J Fijalkowska
Jul 21, 2004·Journal of Bacteriology·Patricia L Foster
Jan 1, 2008·Microbes and Environments·Satoshi Ishii, Michael J Sadowsky
Jul 24, 2012·Genes & Genetic Systems·Tetsuya MoriMasahiro Tatsumi Akiyama
May 5, 2005·PLoS Biology·Ryan T CirzFloyd E Romesberg
Oct 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·E Susan SlechtaJohn R Roth
Mar 25, 2014·Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis·Mei-Chong W LeeNeil J Sargentini
Nov 14, 2012·Annual Review of Genetics·Anna Malkova, James E Haber
Nov 21, 2008·Molecular Microbiology·Elena CurtiRoger Woodgate
Feb 16, 2011·Molecular Microbiology·Thomas E SladewskiPatricia L Foster
Sep 3, 2011·Environmental Microbiology·Jeonghwan JangHor-Gil Hur
Oct 22, 2009·Molecular Microbiology·Jérôme WagnerDominique Burnouf
Dec 18, 2004·Mutation Research·Patricia L Foster
Jun 23, 2004·Research in Microbiology·Megan N HershSusan M Rosenberg
Feb 24, 2006·Mutation Research·Joline ShuTerence M Murphy
Feb 26, 2011·Journal of Medical Microbiology·Anne Jolivet-GougeonPeter Tenke
Nov 20, 2008·FEMS Microbiology Reviews·Antoine Danchin
Sep 22, 2007·FEMS Microbiology Reviews·Ivan ErillJordi Barbé
Dec 27, 2007·Molecular Cell·Veronica G GodoyGraham C Walker
Jul 16, 2008·Journal of Theoretical Biology·J J Bull
May 18, 2016·Nucleic Acids Research·David F LeeXiaoliang S Xie
Oct 6, 2007·Critical Reviews in Biochemistry and Molecular Biology·Patricia L Foster
Oct 6, 2007·Critical Reviews in Biochemistry and Molecular Biology·Ryan T Cirz, Floyd E Romesberg
Jan 1, 2012·Cells·Paul J IppolitiPenny J Beuning
Jun 24, 2015·Journal of Bacteriology·Sarita MallikPatricia L Foster
May 14, 2004·Environmental and Molecular Mutagenesis·Anetta NowosielskaElzbieta Grzesiuk

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