PMID: 376963Apr 1, 1979Paper

Error propagation in viable cells

Mechanisms of Ageing and Development
J Gallant, L Palmer

Abstract

Error propagation is the process, predicted by theoretical models, whereby errors in translating the genetic code will beget fresh errors in successive generations. It has been postulated that error propagation may underly the mortality of cells which display clonal senescence. We have demonstrated the occurrence of error propagation in viable cells of E. coli during growth in a low concentration of streptomycin, a drug which promotes ribosomal ambiguity. We monitored error propagation by measuring mistranslation of a specific UAA codon, and measured viability by direct enumeration of both live and dead cells through a sensitive microscopic technique. We find that the error frequency may be artificially increased by at least an order of magnitude without generating any detectable increase in the proportion of dead cells or of cells whose descendents are doomed to clonal senescence. The error frequency increases gradually over the course of a few generations, in qualitative agreement with the notion of error propagation, and eventually stabilizes at a constant value much higher than normal. The kinetics of this increase agree quantitatively with the Hoffman-Kirkwood and Holliday formulation of error propagation, for parameter va...Continue Reading

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·P Edelmann, J Gallant
Nov 24, 1977·Nature·T B Kirkwood
Sep 15, 1975·Journal of Molecular Biology·T B Kirkwood, R Holliday
Jun 25, 1974·Journal of Molecular Biology·G W Hoffmann
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R T GarvinL Gorini
Apr 1, 1974·Journal of Bacteriology·F N CapaldoS D Barbour
Jan 1, 1974·Molecular & General Genetics : MGG·F BeeftinckN Glansdorff
Aug 1, 1972·The Biochemical Journal·R B Loftfield, D Vanderjagt
Nov 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·L E Orgel
Nov 28, 1970·Nature·C M Lewis, R Holliday
Jul 7, 1972·Nature·R Holliday, G M Tarrant
Apr 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·L E ORGEL
Oct 1, 1963·The Biochemical Journal·R B LOFTFIELD

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Citations

Jan 1, 1981·Molecular & General Genetics : MGG·R F Rosenberger, G Foskett
Jan 1, 1982·Molecular & General Genetics : MGG·N Ellis, J Gallant
May 1, 1996·Journal of Molecular Evolution·D W Schultz, M Yarus
Jul 1, 1980·Mechanisms of Ageing and Development·R F RosenbergerR Holliday
Apr 23, 2002·Molecular Microbiology·Robert DoraziM Zafri Humayun
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C B HarleyS Goldstein
Aug 1, 1983·Biological Reviews of the Cambridge Philosophical Society·S C Makrides
May 8, 2007·Applied and Environmental Microbiology·Covadonga QuirósMario Díaz
Sep 15, 2000·Journal of Bacteriology·M EricssonT Nyström
Nov 27, 2007·Biology Direct·Michael R Rose, Todd H Oakley
Nov 27, 2007·Molecular Microbiology·Fanette FontaineFrançois Taddei
Apr 7, 1985·Journal of Theoretical Biology·C BlombergH Liljenström
May 3, 2001·Redox Report : Communications in Free Radical Research·A Terman
Jun 29, 2006·Annals of the New York Academy of Sciences·Alexei Terman
Oct 10, 2013·FEMS Yeast Research·Thomas Nyström, Beidong Liu
Jun 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D Vinella, R D'Ari
Jan 20, 2017·Open Biology·Tobias von der HaarCampbell W Gourlay
May 1, 1980·Journal of Cellular Physiology·R I Wojtyk, S Goldstein
Jul 23, 1999·Annals of the New York Academy of Sciences·M RadmanF Taddei
Sep 1, 1989·Microbiological Reviews·J Parker
Jul 24, 1985·Biochimica Et Biophysica Acta·M C LuceC L Bunn
Jun 1, 1981·Mechanisms of Ageing and Development·J ParkerJ Gallant
Jan 1, 1982·Experimental Gerontology·M Laughrea

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