Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1

Current Biology : CB
N R CohenA J Furley

Abstract

Neural cell adhesion molecules of the immunoglobulin superfamily (IgCAMs) have been implicated in both the fasciculation and guidance of axons, but direct genetic evidence of a role for neural IgCAMs in axon guidance in vertebrates is lacking. The L1 subfamily of vertebrate neural IgCAMs function as both homophilic and heterophilic receptors for a variety of cell-surface and extracellular ligands and may signal through intracellular kinases or by recruitment of the fibroblast growth factor receptor. L1 itself has been implicated in many neural processes and is expressed widely in the embryonic and adult nervous systems. In humans, mutations in the L1 gene are linked with a spectrum of brain disorders, including loss of the corticospinal tract, but the mechanistic basis for these disorders is unknown. We show that mice that do not express L1 have defects in the guidance of axons of the corticospinal tract, a major motor control pathway projecting from the cortex to the spinal cord. Although the pathway to the caudal medulla appears normal, a substantial proportion of axons fail to cross the midline to the opposite dorsal column as normal. In adults, this results in a reduced decussation and in large numbers of axons projecting i...Continue Reading

References

Jan 1, 1992·Progress in Neurobiology·B B Stanfield
Dec 8, 1991·The Journal of Comparative Neurology·W W ChungJ S Lund
Jan 1, 1990·The Journal of Cell Biology·G KadmonM Schachner
Feb 1, 1986·Journal of Medical Genetics·J HallidayD M Danks
Jan 15, 1993·The Journal of Comparative Neurology·P D MillerS T DeKosky
Oct 1, 1996·Current Opinion in Neurobiology·T Brümmendorf, F G Rathjen
Jan 1, 1997·Molecular and Cellular Neurosciences·H CremerA Represa

❮ Previous
Next ❯

Citations

Oct 22, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S Kenwrick, P Doherty
Jul 21, 2006·Cell and Tissue Research·Kerstin PiechottaMarkus Missler
Mar 1, 2012·Cell and Tissue Research·Michael K E Schäfer, Michael Frotscher
May 4, 2004·Molecular and Cellular Neurosciences·Valérie CastellaniGeneviève Rougon
Jan 22, 2003·Biochemical and Biophysical Research Communications·Ling DongMelitta Schachner
Feb 13, 2001·Brain Research·B RolfU Bartsch
Mar 26, 2003·Developmental Biology·Ronelle J Hall, Carol A Erickson
Sep 22, 2001·Physiology & Behavior·A V AnagnostopoulosM T Davisson
Jul 15, 1999·Physiology & Behavior·K A Clarke, J Still
Jan 13, 2001·Brain Research. Developmental Brain Research·E N OrlinoP E Phelps
Feb 15, 2001·Brain Research. Developmental Brain Research·G P DemyanenkoP F Maness
Sep 15, 2001·Brain Research. Developmental Brain Research·B D MitchellS R D'Mello
Sep 12, 2002·Biochimica Et Biophysica Acta·Takashi Angata, Els Brinkman-Van der Linden
Oct 6, 1999·Current Opinion in Cell Biology·S Murase, E M Schuman
May 30, 2001·Current Opinion in Genetics & Development·G Casari, E Rugarli
May 6, 1998·Current Opinion in Neurobiology·T BrümmendorfF G Rathjen
Apr 5, 2003·Molecular and Cellular Neurosciences·Ling DongMelitta Schachner
Oct 6, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sonja E SteigenTorsten O Nielsen
Sep 2, 2005·Nature Reviews. Neuroscience·Diane L Sherman, Peter J Brophy
Jul 22, 2006·Nature Reviews. Neuroscience·Noam Y Harel, Stephen M Strittmatter
May 5, 1999·Journal of Anatomy·E A Joosten, D P Bär
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·M DottoriA W Boyd
Mar 21, 2012·The Journal of Biological Chemistry·David LutzRalf Kleene
Jun 14, 2012·The Journal of Biological Chemistry·Lujia ZhouBart De Strooper
Mar 11, 2009·The Journal of Experimental Medicine·Luigi MaddalunoUgo Cavallaro
Apr 10, 2002·Journal of Neurotrauma·Yu-Shang LeeRichard T Robertson
Oct 28, 2003·Journal of Neurotrauma·Chanland RoonprapuntWise Young
Jun 16, 2001·Molecular Biology of the Cell·G SchürmannH P Erickson
Apr 7, 2006·Molecular Biology of the Cell·John D WhittardDan P Felsenfeld
Jul 24, 2012·Brain : a Journal of Neurology·Maha S ZakiAna Maria Grijalvo-Perez
Apr 8, 2009·Cerebral Cortex·Libing ZhouAndre M Goffinet
Jun 26, 2010·Cerebral Cortex·Galina P DemyanenkoPatricia F Maness
Jul 21, 2009·Human Molecular Genetics·Kakanahalli NagarajMichael Hortsch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.