Errors in prostate core biopsy diagnosis in an era of specialisation and double reporting.

Journal of Clinical Pathology
Cornelia Margaret Szecsei, Jon D Oxley

Abstract

To examine the effects of specialist reporting on error rates in prostate core biopsy diagnosis. Biopsies were reported by eight specialist uropathologists over 3 years. New cancer diagnoses were double-reported and all biopsies were reviewed for the multidisciplinary team (MDT) meeting. Diagnostic alterations were recorded in supplementary reports and error rates were compared with a decade previously. 2600 biopsies were reported. 64.1% contained adenocarcinoma, a 19.7% increase. The false-positive error rate had reduced from 0.4% to 0.06%. The false-negative error rate had increased from 1.5% to 1.8%, but represented fewer absolute errors due to increased cancer incidence. Specialisation and double-reporting have reduced false-positive errors. MDT review of negative cores continues to identify a very low number of false-negative errors. Our data represents a 'gold standard' for prostate biopsy diagnostic error rates. Increased use of MRI-targeted biopsies may alter error rates and their future clinical significance.

References

Jan 23, 2003·The Prostate·Joseph D KronzJonathan I Epstein
Feb 27, 2004·BJU International·T H Van der KwastR F Hoedemaeker
Nov 26, 2009·The American Journal of Surgical Pathology·Tineke WoltersGeert J L H van Leenders
Mar 29, 2011·Histopathology·Jon D Oxley, Chandan Sen
Jan 4, 2012·Histopathology·Jonathan I Epstein

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Citations

Nov 20, 2020·Journal of Clinical Pathology·Murali VarmaDaniel M Berney

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