Errors in the conduct of systematic reviews of pharmacological interventions for irritable bowel syndrome

The American Journal of Gastroenterology
Alexander C FordPaul Moayyedi

Abstract

Systematic reviews and meta-analyses are integral to evidence-based clinical decision making. Although flawed systematic reviews could compromise optimal decision making, their accuracy has received limited investigation. We assessed conduct of systematic reviews of pharmaceutical interventions for irritable bowel syndrome (IBS). We searched MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews (up to June 2008) to identify and replicate all published systematic reviews and meta-analyses that examined pharmacological interventions for IBS. We identified trials appropriately and inappropriately included according to the investigators' own eligibility criteria and eligible trials the investigators failed to include, and assessed the accuracy of dichotomous data extraction from all truly eligible trials. We conducted meta-analyses of accurate data from all truly eligible trials, and examined the differences between these accurate estimates and those reported by the authors. The search strategy identified 120 citations, and 13 appeared to be relevant. Five systematic reviews did not extract dichotomous data, leaving eight eligible for inclusion. In five of the eight meta-analyses 13-29% of included trials were ineligible...Continue Reading

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Citations

Jun 14, 2012·BMC Medical Research Methodology·Felicity A Goodyear-SmithChris Del Mar
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Mar 17, 2011·The American Journal of Gastroenterology·Alexander C FordPaul Moayyedi
Mar 17, 2011·The American Journal of Gastroenterology·Alexander C FordPaul Moayyedi
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