PMID: 8939626Oct 1, 1996Paper

Errors of heterologous protein expression

Current Opinion in Biotechnology
C Kurland, J Gallant

Abstract

Missense substitutions and processivity errors in the translation of heterologous proteins are expected to occur at higher frequencies than the corresponding errors of normal translation. The resulting error-containing products may overload chaperone systems. Likewise, there may be a risk of an immunogenic response to heterologous proteins introduced into vertebrates. Recent work has been carried out on the mechanisms by which such errors arise and on their occurrence in cloned, heterologous gene products.

References

Feb 1, 1978·Journal of Bacteriology·S Gottesman, D Zipser
Aug 1, 1992·Trends in Biochemical Sciences·C Georgopoulos
Jul 22, 1991·FEBS Letters·C G Kurland
Oct 20, 1990·Journal of Molecular Biology·F Jørgensen, C G Kurland
Sep 1, 1989·Microbiological Reviews·J Parker
Mar 1, 1986·Molecular & General Genetics : MGG·O FayetC Georgopoulos
Mar 1, 1986·Molecular & General Genetics : MGG·A J JenkinsM Masters
Dec 1, 1988·Genes & Development·D B StrausC A Gross
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R A Spanjaard, J van Duin
Jun 20, 1973·Nature: New Biology·A I Bukhari, D Zipser
Dec 1, 1973·Journal of Bacteriology·B Shineberg, D Zipser
Jan 1, 1968·Molecular & General Genetics : MGG·J Langridge
Jun 1, 1983·Microbiological Reviews·B J Bachmann
May 5, 1995·Journal of Molecular Biology·H Dong, C G Kurland
Mar 5, 1993·Journal of Molecular Biology·F JørgensenC G Kurland
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D Lindsley, J Gallant
Mar 8, 1996·Journal of Molecular Biology·Z BarakJ Gallant

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Citations

Sep 8, 2010·Applied Microbiology and Biotechnology·Najla GasmiJean-Marc Nicaud
Nov 5, 2011·Applied Microbiology and Biotechnology·Norma WelschThomas Schweder
Feb 10, 2004·Protein Expression and Purification·Zhiyong ZhouAltaf A Lal
Oct 19, 2001·Molecular and Biochemical Parasitology·O CinquinR I Menz
Oct 3, 2002·Protein Expression and Purification·Maria L B MagalhãesDiógenes S Santos
Feb 25, 2003·Protein Expression and Purification·Dean E McNultyJames F Kane
May 6, 2003·Protein Expression and Purification·Louisa M MacDonaldJames A Reynoldson
Mar 26, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hans Peter SørensenKim Kusk Mortensen
Mar 26, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xiaoqiu Wu, Udo Oppermann
Mar 28, 2009·Journal of the Royal Society, Interface·Mark WelchJeremy Minshull
Apr 7, 2005·Applied and Environmental Microbiology·Gerald D BaldridgeUlrike G Munderloh
Dec 30, 2009·Journal of Bacteriology·Hong-Suk KimHiroshi Nikaido
Oct 27, 2012·Journal of Clinical Microbiology·Brenden C SmithCaroline E Cameron
Jun 8, 2006·BMC Bioinformatics·Alan VillalobosSridhar Govindarajan
Oct 23, 2012·BMC Systems Biology·Bevan Kai-Sheng Chung, Dong-Yup Lee
Jul 24, 2013·Journal of Biotechnology·Bevan Kai-Sheng ChungDong-Yup Lee
Apr 1, 2014·Applied Microbiology and Biotechnology·Mizuki TanakaKatsuya Gomi
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·J A Gallant, D Lindsley
Sep 30, 2014·Trends in Molecular Medicine·Vincent P Mauro, Stephen A Chappell
Sep 16, 2014·FEBS Letters·Adil MoghalMichael Ibba
Dec 17, 2008·Protein Expression and Purification·Karl A HassanMelissa H Brown
Jun 26, 2007·Gene·Houhui Song, Michael Niederweis
Jan 24, 2007·Protein Science : a Publication of the Protein Society·J Colin CoxHomme W Hellinga
Dec 21, 2004·Journal of Biotechnology·Hans Peter Sørensen, Kim Kusk Mortensen
Aug 16, 2006·Protein Expression and Purification·Renu Chandrasekaran, Martin Thompson
Feb 18, 2006·Journal of Molecular Biology·Lisa M JungbauerSilvia Cavagnero

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