Ertapenem resistance in 2 tertiary-care hospitals: Microbiology, epidemiology, and risk factors

Enfermedades infecciosas y microbiología clínica
Natalia Andrea MaldonadoJaime Robledo

Abstract

Carbapenems resistance is a growing phenomenon and a threat to public health because of the reduced therapeutic options for resistant infections. A retrospective case-control study was conducted in 2 tertiary-care hospitals in Medellín, Colombia. Fifty patients infected with ertapenem-resistant enterobacteriaceae were compared with a control group consisting of 100 patients with infections caused by ertapenem susceptible enterobacteriaceae. A multivariate logistic regression model was used to identify factors that best explain ertapenem-resistant enterobacteriaceae infections. The factors associated with ertapenem-resistant enterobacteriaceae infections were prior exposure to carbapenems (adjusted OR 3.43; 95% IC 1.08-10.87) and prior exposure to cefepime (adjusted OR 6.46; 95% IC 1.08-38.38). Prior exposure to antibiotics is the factor that best explains the ertapenem-resistant enterobacteriaceae infection in this population, highlighting the importance of antimicrobial stewardship programs in hospitals.

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Citations

Oct 19, 2017·Antimicrobial Agents and Chemotherapy·Karlijn van LoonMargreet C Vos
Jan 10, 2021·Journal of Visceral Surgery·M K CollardUNKNOWN Société français de chirurgie digestive (SFCD) et la Société d’imagerie abdominale et digestive (SIAD)

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