PMID: 1008057Jan 1, 1976

Erthropoietic precursors in mice with phenylhydrazine-induced anemia

American Journal of Hematology
H Hara, M Ogawa


Using a methylcellulose cell culture technique, we studied the serial changes in erythropoietic precursors in the femur, spleen, and blood of mice under erythropoietic stimuli. Phenylhdrazine hydrochloride, in the dosage of 60 mg/kg, was injected into mice subcutaneously on days 0, 1, and 3, and mice were sacrified on days 0, 2, 4, 7, and 10 for assessment of erythropoietic precursors. Significant changes were observed for all hemopoietic organs in the number of erythrocytic burst-forming units (BFU-E) and erythrocytic colony-forming units (CFU-E). Only BFU-E were present in blood, and their maximal increase was noted on day 2. While marrow BFU-E continuously decreased, maximal increase of CFU-E noted on day 4. Splenic BFU-E and CFU-E increased until day 4 and declined subsequently. These observations suggest the presence of significant migration of BFU-E in mice under erythropoietic stimuli and stress the importance of studies on all hemopoietic organs in the assessment of murine hemopoiesis.


Jul 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J R StephensonM M Shreeve
Jun 1, 1973·Journal of Cellular Physiology·C J GregoryJ E Till
May 1, 1971·British Journal of Haematology·K A RickardF Stohlmann


Jul 1, 1987·Cell and Tissue Kinetics·V G Tyazhelova
Sep 1, 1985·Scandinavian Journal of Haematology·C Butin, J P Blanchet
Jan 1, 1984·Cell and Tissue Kinetics·R E Ploemacher, N H Brons
Nov 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·H M Leng, P I Folb
Dec 3, 2003·The Journal of Biological Chemistry·Xiangdong FangQiliang Li
Feb 21, 2008·The Journal of Biological Chemistry·Adele R GordonPaul R Kemp
Mar 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Shan Soe-LinPrem Ponka
Nov 1, 1977·Scandinavian Journal of Haematology·R E PloemacherO Vos
May 26, 1998·Environmental Health Perspectives·R E Parchment
Apr 7, 2007·Current Opinion in Hematology·Merav Socolovsky
Dec 14, 2004·Blood·Laurie E LenoxRobert F Paulson
Feb 18, 2011·Journal of Bone and Mineral Metabolism·María del Pilar MartínezMaría Inés Conti
Mar 5, 2011·Current Opinion in Hematology·Robert F PaulsonDai-Chen Wu
Jun 10, 2011·PloS One·Yu-An CaoChristopher H Contag
Mar 29, 2013·The Journal of Toxicological Sciences·Toshio KobayashiKotaro Furukawa
Apr 5, 2017·The Journal of Clinical Investigation·Moon-Suhn RyuCaroline C Philpott
Mar 12, 2020·Cells·Robert F PaulsonYuanting Chen
Dec 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·T R LappinJ M Bridges
Jul 1, 1982·British Journal of Haematology·J Mladenovic, J W Adamson
Nov 1, 1990·British Journal of Haematology·O CynshiK Hirashima
Aug 3, 2007·The Journal of Clinical Investigation·Dragan MarinkovicSaghi Ghaffari
Dec 1, 1985·Environmental Health Perspectives·M D Shetlar, H A Hill
Nov 1, 1985·Cell and Tissue Kinetics·A H PiersmaC P Ottenheim
Mar 1, 1996·Parasitology·A D SullivanS R Meshnick
Nov 12, 2015·BioMed Research International·Shun Maekawa, Takashi Kato
Jan 1, 1988·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J Westermann, R Pabst
Jul 26, 2008·American Journal of Physiology. Renal Physiology·Tania VeutheyMarta Elena Roque

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