Erucic acid, a component of Lorenzo's oil and PPAR-δ ligand modifies C6 glioma growth and toxicity of doxorubicin. Experimental data and a comprehensive literature analysis

Chemico-biological Interactions
M A AltinozIlhan Elmaci

Abstract

PPAR-δ is a transcription factor which has crucial roles in stimulating oligodendroglial differentiation and myelination and its activation was also shown to differentiate malignant C6 glioma cells into oligodendrocytes. One of the ligands of PPAR-δ is erucic acid (EA), an edible omega-9 fatty acid consumed more by Asian populations and exists highly in Chinese womens milk. There exist epidemiological evidence that pediatric brain tumor incidence is among the lowest in the Chinese population. EA is also an ingredient of Lorenzo's oil used against adrenoleukodystrophy, a pediatric demyelinating disease. EA was inappropriately assumed as a strong cardiotoxin based on Spanish oil syndrome, caused by toxic-aniline dye refined rapeseed oil. In this study, we studied whether EA is capable to block growth of C6 glioma cells and modify cardiotoxicity of doxorubicin. We studied effects of EA on the 3-dimensional appearance of the adherent cells, soft agar colony formation and S-phase in the 3-dimensional spheroids in C6 glioma cell cultures. We also investigated the effects of EA on hepatic and cardiac toxicity of doxorubicin. EA decreased in vitro growth of C6 glioma cells at therapeutically achievable concentrations. EA effects were m...Continue Reading

Citations

Oct 19, 2019·Metabolic Brain Disease·Meric A AltinozEmily Hacker
Jan 26, 2021·Plant Foods for Human Nutrition·Paweł PaśkoShela Gorinstein
Oct 16, 2020·Nutritional Neuroscience·J B Senthil Kumar, Bhawna Sharma
Nov 17, 2021·Journal of Toxicology and Environmental Health. Part a·W M F SilvaA R G Dias

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