PMID: 8599479Dec 1, 1995Paper

Eruptive epithelioid hemangioendothelioma with spindle cells

The American Journal of Dermatopathology
A B KanikJ Bhawan

Abstract

A 39-year-old white man presented with four discrete dermal nodules in his right upper arm. Biopsy revealed superficial dermal well-circumscribed nodules composed of solid areas and vascular spaces lined by epithelioid endothelial cells and a similar nodule composed of spindle and epithelioid cells. A moderate mitotic count of 3-4 mitoses/10 hpf was present. Multiple lesions erupted 1 month later distally and proximally to the original lesions. Magnetic resonance imaging of the right arm demonstrated a lesion in the humerus. Biopsy of the humerus showed a vascular tumor with similar histologic features to the overlying skin lesions. The differential diagnosis included epithelioid vascular tumors, bacillary angiomatosis, pyogenic granuloma, and Kaposi sarcoma. Vascular lesions containing epithelioid and spindle cells span a spectrum from benign to malignant. We believe these tumors belong in the category of hemangioendothelioma and propose the name eruptive epithelioid hemangioendothelioma with spindle cells. Our case emphasizes that eruptive cutaneous vascular lesions do not always suggest immunosuppression or malignancy. Additionally, it highlights the association between epithelioid vascular lesions of the skin and bone.

Citations

Dec 17, 1998·The American Journal of Dermatopathology·M QuanteP H McKee
Jan 24, 2008·The American Journal of Dermatopathology·Omar P SangüezaLuis Requena
Jan 19, 2013·Seminars in Diagnostic Pathology·Luis Requena, Heinz Kutzner
Oct 14, 2008·Chirurgie de la main·T El HarroudiA Jalil
Feb 19, 2008·Journal of the American Academy of Dermatology·Alan S BoydBrent Pennington
Nov 1, 1996·Journal of the American Academy of Dermatology·A B KanikJ Bhawan
Jul 20, 1999·Dermatologic Clinics·V G Prieto, C R Shea
Apr 12, 2016·International Journal of Dermatology·Sung-Min ParkJe-Ho Mun
Mar 18, 2015·Pediatric Dermatology·Carmen Carranza-RomeroLuis Requena
Aug 26, 1998·The Journal of Dermatology·N KatoM Okushiba
Dec 22, 2017·The American Journal of Surgical Pathology·Mar Llamas-VelascoHeinz Kutzner
Jan 15, 2008·Journal of Cutaneous Pathology·Loren E ClarkeJacqueline Junkins-Hopkins
Feb 13, 2008·Histopathology·S G N Goh, E Calonje

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