Eryptosis-inducing activity of bisphenol A and its analogs in human red blood cells (in vitro study)

Journal of Hazardous Materials
Aneta MaćczakJaromir Michałowicz

Abstract

Bisphenols are important chemicals that are widely used in the manufacturing of polycarbonates, epoxy resin and thermal paper, and thus the exposure of humans to these substances has been noted. The purpose of this study was to assess eryptotic changes in human erythrocytes exposed (in vitro) to bisphenol A (BPA) and its selected analogs, i.e.,bisphenol F (BPF), bisphenol S (BPS) and bisphenol AF (BPAF). The erythrocytes were incubated with compounds studied at concentrations ranging from 1 to 250μg/mL for 4, 12 or 24h. The results showed that BPA and its analogs increased cytosolic calcium ions level with the strongest effect noted for BPAF. It has also been revealed that all bisphenols analyzed, and BPAF and BPF in particular increased phosphatidylserine translocation in red blood cells, which confirmed that they exhibited eryptotic potential in this cell type. Furthermore, it was shown that BPA and its analogs caused significant increase in calpain and caspase-3 activities, while the strongest effect was noted for BPAF. BPS, which is the main substituent of bisphenol A in polymers and thermal paper production exhibited similar eryptotic potential to BPA. Eryptotic changes in human erythrocytes were provoked by bisphenols at ...Continue Reading

References

Jul 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·G N Rao
May 9, 2002·Water Research·Hermann FrommeAndrea Wenzel
Apr 18, 2003·Cell Death and Differentiation·K S LangS M Huber
Jan 18, 2006·Neuroscience Letters·Minghui Jessica ChenNam Sang Cheung
Aug 21, 2007·Reproductive Toxicology·Ruth A KeriGail S Prins
Dec 18, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Florian LangMichael Foller
Feb 6, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yuan-Jie LiXiao-Lin Wu
Aug 27, 2009·Journal of Occupational Health·Yonghua HeDe-Kun Li
Sep 4, 2009·The Journal of Membrane Biology·Davide BarrecaErsilia Bellocco
Mar 27, 2010·Environmental Health Perspectives·Laura N VandenbergGilbert Schoenfelder
May 22, 2010·Environmental Health Perspectives·Paloma Alonso-MagdalenaAngel Nadal
May 27, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Florian LangMichael Föller
Nov 30, 2010·Archives of Toxicology·Onur Kenan Ulutaşİsmet Çok
Jul 21, 2011·Drug and Chemical Toxicology·Chun-Chi KuoChung-Ren Jan
Dec 3, 2011·Journal of Agricultural and Food Chemistry·Mohanad ZbidahFlorian Lang
Dec 17, 2011·American Journal of Physiology. Cell Physiology·Oliver BorstFlorian Lang
Jan 18, 2012·Molecular and Cellular Endocrinology·Frederick S Vom SaalJulia A Taylor
May 18, 2012·Environmental Science & Technology·Chunyang LiaoKurunthachalam Kannan
Jun 26, 2012·Toxicology·Adrian LupescuFlorian Lang
Aug 9, 2012·The Biochemical Journal·Adam WieschhausAthar H Chishti
Sep 22, 2012·Neurotoxicity Research·Soyoung LeeSang-Hyun Kim
Mar 6, 2013·Environmental Health Perspectives·René Viñas, Cheryl S Watson
Nov 13, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Majed AbedFlorian Lang
Mar 19, 2014·Environmental Toxicology and Pharmacology·Jaromir Michałowicz
Jul 9, 2014·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Hamdy A IbrahimRania A Abd Elazim
Sep 3, 2014·Biochemistry Research International·Hiral SutharY T Jasrai
Feb 1, 2015·Seminars in Cell & Developmental Biology·Elisabeth Lang, Florian Lang
Mar 31, 2015·BioMed Research International·Elisabeth Lang, Florian Lang
Aug 2, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Aneta MaćczakJaromir Michałowicz

❮ Previous
Next ❯

Citations

Jun 14, 2016·Cell Biochemistry and Function·Elena SignorettoFlorian Lang
Feb 20, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Majed AbedAlfred Königsrainer
Feb 22, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Mustafa AlmasryCaterina Faggio
Mar 6, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Aneta MaćczakJaromir Michałowicz
Nov 21, 2017·Archives of Toxicology·Jie ZhangTiehua Zhang
Aug 10, 2018·Toxicology Research·Michael ThoeneJoanna Wojtkiewicz
Jun 17, 2020·Journal of Feline Medicine and Surgery·Simona KovaříkováJarmila Konvalinová
May 26, 2017·International Journal of Cancer. Journal International Du Cancer·Elisabeth LangFlorian Lang
Jun 12, 2019·Environmental Health and Preventive Medicine·Asad UllahSarwat Jahan
Feb 18, 2017·Applied Microbiology and Biotechnology·Chao HuangLinshan Liu
Oct 31, 2017·Environmental Science and Pollution Research International·Ewa Olchowik-GrabarekMaria Zamaraeva
Aug 28, 2020·International Journal of Molecular Sciences·Lars KaiserHans-Peter Deigner
Jul 15, 2020·Environmental Pollution·Xiyan MuChengju Wang
Jan 14, 2021·Pilot and Feasibility Studies·Todd HagobianSuzanne Phelan
Mar 5, 2021·Toxicology·Gopalapura J VishalakshiKesturu S Girish
May 6, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Saleh M Abdullah, Hina Rashid
Apr 10, 2021·BioMed Research International·E BarallaV Pasciu
Oct 5, 2021·Frontiers in Cellular and Infection Microbiology·Andrew J JezewskiAudrey R Odom John
Apr 1, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Syeda Tayyaba Batool KazmiIhsan Ul Haq

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Jaromir MichałowiczAgata Bąk
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Katarzyna MokraJaromir Michałowicz
© 2022 Meta ULC. All rights reserved