Erysipelothrix rhusiopathiae: association of Spa-type with serotype and role in protective immunity

Vaccine
Alaina L IngebritsonPaul J Hauer

Abstract

A collection of swine, fish, and cetacean Erysipelothrix rhusiopathiae strains representing 16 serotypes was analyzed for possession of the three currently recognized surface protective antigen (spa)-types: spaA, spaB, and spaC. Polymerase chain reaction (PCR) assays and Western blotting with a SpaA-specific monoclonal antibody demonstrated that spa-type is not confined to specific serotype groups. In particular, the spa-type of strains of aquatic origin was more variable than those of terrestrial origin, and possessed the distinct ability to express more than one spa. In a cross-protection study, mice immunized with an E. rhusiopathiae serotype 2 SpaA-type strain and challenged with various E. rhusiopathiae isolates were completely protected against strains exhibiting a single homologous spa, but variably protected against strains possessing a heterologous spa or those harboring more than one spa-type.

References

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Citations

Jul 31, 2013·Biologicals : Journal of the International Association of Biological Standardization·A Walker, G B Srinivas
Jan 14, 2016·Diseases of Aquatic Organisms·Mar MeleroJosé Manuel Sánchez-Vizcaíno
Mar 26, 2014·Avian Pathology : Journal of the W.V.P.A·Helena ErikssonDésirée S Jansson
Jan 11, 2011·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Joseph S BenderTanja Opriessnig
Mar 10, 2018·The Veterinary Record·Priscilla F GerberTanja Opriessnig
Mar 12, 2019·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Yoshihiro ShimojiMasahiro Eguchi
Mar 27, 2012·The Journal of Veterinary Medical Science·Ho ToTetsuji Nagano
May 1, 2020·Frontiers in Veterinary Science·Tanja OpriessnigYoshihiro Shimoji

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