Erythema and Acclimatization Following Repeated Sun Exposure: A Modeling Study.

Photochemistry and Photobiology
B L Diffey

Abstract

The development of a computational model is described that allows time-varying erythema and acclimatization to be determined following repeated exposure to solar ultraviolet (UV) radiation. Good agreement was observed between experimental data and model predictions. Results are presented that illustrate how daily, adventitious sun exposure over the course of a year can result in occasional erythema generally in the late spring/early summer, while at the same time showing how the photoadaptive response of the skin changes throughout the year at different latitudes and for different sun-reactive skin types. The model is predicated on three physiological responses; the erythemal response as a function of increasing UV dose, the time courses of erythema and adaptation in response to a single UV exposure. Mathematical models complement observational data and the outputs from the model may help in planning future experimental studies, as well as providing insights into mechanistic responses.

References

Nov 1, 1991·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·B L Diffey, P M Farr
Oct 1, 1986·Photochemistry and Photobiology·P M Farr, B L Diffey
Jan 1, 1986·The British Journal of Dermatology·B L Diffey, P M Farr
Jul 1, 1985·The British Journal of Dermatology·P M Farr, B L Diffey
Jun 1, 1965·Photochemistry and Photobiology·J C van der Leun
Dec 1, 1984·The British Journal of Dermatology·P M Farr, B L Diffey
Aug 1, 1982·Photochemistry and Photobiology·J A ParrishR R Anderson
May 1, 1981·The Journal of Investigative Dermatology·K H Kaidbey, A M Kligman
Jul 1, 1981·The Journal of Investigative Dermatology·D J Cripps
Oct 1, 1981·Journal of the American Academy of Dermatology·R M SayreE Marlowe
Jun 1, 1995·Journal of Public Health Medicine·J Melia, A Bulman
Apr 1, 1996·Photodermatology, Photoimmunology & Photomedicine·S GonzalezN Kollias
Sep 21, 2001·The Journal of Investigative Dermatology·S de WinterS Pavel
Sep 17, 2002·Methods : a Companion to Methods in Enzymology·Graham I Harrison, Antony R Young
May 1, 1959·Journal of the National Cancer Institute·H F BLUMG A SOFFEN
Feb 1, 1993·Current Biology : CB·W D Hillis
Sep 10, 2005·Photodermatology, Photoimmunology & Photomedicine·Alison HennessyBrian Diffey
Apr 8, 2006·The Journal of Investigative Dermatology·Roy A PalmerAntony R Young
Jan 23, 2008·Photochemistry and Photobiology·Brian Diffey
Jul 26, 2008·Annals of Epidemiology·Leslie K DennisJulie A Coughlin
Oct 16, 2013·The British Journal of Dermatology·S DarnéP J Hampton
Nov 29, 2016·JAMA Dermatology·Padmini SubramaniamUNKNOWN QSkin Sun and Health Study Investigators
Mar 8, 2017·Experimental Dermatology·Frank R de Gruijl
Oct 27, 2017·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Brian L Diffey, Peter M Farr
Jun 22, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·M GarmynS A Miller
Jan 23, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·A PacificoA Morrone
Apr 17, 2020·JAMA : the Journal of the American Medical Association·Nicholas P JewellBritta L Jewell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.