Erythema Nodosum as the Initial Presentation of Nivolumab-Induced Sarcoidosis-Like Reaction

Journal of Cutaneous Medicine and Surgery
Alexandre LarocheMarc-André Doré

Abstract

We report a case of nivolumab-related sarcoidosis-like syndrome that initially presented with erythema nodosum. Sarcoidosis development has been described in single and combination immunotherapy. A 68-year-old white woman with metastatic ocular amelanotic choroid melanoma was treated with nivolumab. The patient developed histologically confirmed erythema nodosum lesions and pulmonary granuloma sarcoidosis. Nivolumab was discontinued and the patient started ipilimumab therapy. Sarcoidosis-like syndrome with lymphadenopathy is a rare adverse event that is important to recognize since it can be mistaken for metastatic disease progression. Tissue biopsy of new lesions during immunotherapy is an important step in patient evaluation.

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Citations

Jan 19, 2019·The Australasian Journal of Dermatology·Myoung Eun ChoiWoo Jin Lee
Jul 20, 2019·International Journal of Clinical Oncology·Pooja H RambhiaMeg R Gerstenblith
Nov 24, 2020·Expert Review of Pharmacoeconomics & Outcomes Research·Pol Specenier
Apr 23, 2020·Journal of the American Academy of Dermatology·Anne Birgitte SimonsenClaus Zachariae
Aug 2, 2021·Journal of the American Academy of Dermatology·Henry T QuachAnna K Dewan
Nov 24, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Isabella Pospischil, Wolfram Hoetzenecker
Nov 24, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Isabella Pospischil, Wolfram Hoetzenecker

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Methods Mentioned

BETA
biopsies
biopsy

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