PMID: 15361954Sep 14, 2004Paper

Erythema nodosum leprosum case series report: clinical profile, immunological basis and treatment implemented in health services

Revista Da Sociedade Brasileira De Medicina Tropical
Jackeline Gomes GuerraMaurício Barcelos Costa

Abstract

Erythema nodosum leprosum is an acute inflammatory event in the chronic course of leprosy. It is considered an immunological disorder and an important cause of morbidity and disability. We evaluate the clinical profile, serology and histopathology 58 erythema nodosum leprosum patients sequentially recruited, from July- December 2000, in an endemic area in Central Brazil (Goiás State). Half of the reactins were considered severe and 66% of the cases had the first episode of reaction during specific treatment. The majority of patients and controls were positive to anti-PGL-I IgM. The more frequent histopathological findings in erythema nodosum leprosum were presence of intracellular acid-fast bacilli, perivascular/peradnexial mononuclear inflammatory infiltrate, and neural aggression. Ninety six percent of the patients were treated with systemic steroid in the first episode. The results point out to the association between ENL and neuritis and the rare adoption of thalidomide as a solely medication in the health services.

References

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Citations

May 28, 2019·Pharmacogenomics·Perpétua do Socorro Silva CostaFernanda Sales Luiz Vianna
May 3, 2020·International Journal of Dermatology·Caroline Baima de MeloEuzenir Nunes Sarno
Dec 15, 2011·BMC Infectious Diseases·Luciana Silva RodriguesMaria Cristina Vidal Pessolani
Jun 22, 2010·Revista Da Sociedade Brasileira De Medicina Tropical·Márcia Almeida Galvão TeixeiraEmmanuel Rodrigues de França
Mar 27, 2021·Indian Journal of Dermatology, Venereology and Leprology·Fátima Regina Vilani-MorenoMarcos da Cunha Lopes Virmond

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