Erythema nodosum-like lesions during BRAF inhibitor therapy: Report on 16 new cases and review of the literature

Journal of the European Academy of Dermatology and Venereology : JEADV
R MössnerS Ugurel

Abstract

BRAF inhibitors have been licensed for the therapy of BRAF-mutated melanoma. Recently, inflammatory skin lesions clinically resembling erythema nodosum have been reported as therapy side-effects that may lead to treatment discontinuation. To identify and characterize cases with BRAF inhibitor-associated erythema nodosum-like inflammatory skin lesions and development of an algorithm for their management. Retrospective chart review of melanoma patients treated with BRAF inhibitors in 14 departments of Dermatology in Germany and Austria and PubMed search for cases in the literature. Sixteen patients were identified who developed erythema nodosum-like lesions under BRAF inhibitor therapy; 14 had received vemurafenib and two dabrafenib plus trametinib. The most frequently involved body sites were the legs. Histopathology was performed in five cases and revealed panniculitis in three and vasculitis in two patients respectively. Arthralgia and fever were associated symptoms in 44% and 31% of patients respectively. Inflammatory symptoms led to discontinuation of treatment in three patients, while in the majority of cases symptomatic management was sufficient. Skin lesions finally resolved despite continued BRAF inhibitor therapy in sev...Continue Reading

References

May 15, 1998·The British Journal of Dermatology·K M AclandP M Dowd
Nov 12, 1998·Journal of the American Academy of Dermatology·J CottonA F Hood
Jun 16, 2006·The New England Journal of Medicine·Sarit AssoulineCarlo Gambacorti-Passerini
Jun 7, 2011·The New England Journal of Medicine·Paul B ChapmanUNKNOWN BRIM-3 Study Group
Jul 26, 2012·Melanoma Research·Jean-Benoît MonfortCéleste Lebbé
Oct 2, 2012·The New England Journal of Medicine·Keith T FlahertyJeffrey Weber
Nov 20, 2012·Journal of the American Academy of Dermatology·Roberto A NovoaMeg R Gerstenblith
Feb 20, 2013·European Journal of Dermatology : EJD·Annette DegenRalf Gutzmer
Apr 10, 2013·European Journal of Dermatology : EJD·Axel Patrice VillaniLuc Thomas
Apr 16, 2013·Journal of Cutaneous Pathology·Gene H KimGoli Compoginis
Apr 25, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·V BrazzelliG Borroni
May 30, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rishika SinhaLouise Fearfield
Sep 17, 2013·Annales de dermatologie et de vénéréologie·V SibaudJ-P Delord
Nov 22, 2013·The Annals of Pharmacotherapy·Van Anh TrinhKevin B Kim
Feb 19, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·A ChaminadeA Pham-Ledard
Mar 8, 2014·Pediatric Dermatology·Emily S WestJoseph G Morelli
Mar 20, 2014·British Journal of Cancer·M HolderfieldD D Stuart

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Citations

Sep 5, 2015·Current Treatment Options in Oncology·Silvina B PuglieseBernice Y Kwong
Jan 31, 2017·The American Journal of Dermatopathology·Jonathan J LeeMai P Hoang
May 20, 2017·Pediatric Dermatology·Nika FineltBrandi M Kenner-Bell
Mar 27, 2018·Pediatric Dermatology·Trisha BhatCarrie C Coughlin
Feb 28, 2018·Melanoma Research·Florentia DimitriouJoanna Mangana
Nov 15, 2018·Cancer Biology & Therapy·Nina Anika RicharzMaria Teresa Fernández-Figueras
Mar 10, 2016·The American Journal of Dermatopathology·Igor Vázquez-OsorioHugo Vázquez-Veiga
Jun 18, 2019·SAGE Open Medical Case Reports·Marco Aj IafollaElaine McWhirter
May 26, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A BoadaJ Malvehy
Dec 14, 2018·Future Oncology·Maya HabreHampig Raphael Kourie
Jun 15, 2017·Case Reports in Dermatology·Miruna NegulescuNicolas Meyer
Aug 3, 2019·Advances in Rheumatology·Thâmara Cristiane Alves Batista MoritaJozelio Freire de Carvalho
Oct 22, 2020·Cancers·Martin SalzmannJessica C Hassel
Nov 10, 2020·Skeletal Radiology·David J BartlettKatrina N Glazebrook
Aug 31, 2019·Dermatologic Clinics·Leonora BomarChristine Ahn
Mar 2, 2021·Immunotherapy·Sang T KimMaria E Suarez-Almazor
Sep 20, 2020·Annales de dermatologie et de vénéréologie·M PirothG Quéreux

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