Erythema Nodosum Masking Kawasaki Disease with an Initial Manifestation of Skin Lesions

Yonsei Medical Journal
Seigo OkadaTakashi Maki

Abstract

We report the first case demonstrating an association between Kawasaki disease (KD) and erythema nodosum (EN). A 3-year-old girl presented with EN as an initial manifestation of KD. At the initial visit, she showed high fever of 40°C, injection of the oropharynx, cervical lymphadenopathy, and red-purple cutaneous nodules, particularly on the lower limbs. She complained of severe pain in the neck and cutaneous lesions. Initially, the development of EN was attributed to Salmonella spp infection, which was detected in stool culture. However, the patient did not respond to high-dose ampicillin/sulbactam to which the Salmonella spp is sensitive. Echocardiography performed as screening for fever of unknown origin revealed medium-sized aneurysms of the left anterior descending artery. EN masked the diagnosis of KD, and the patient developed a coronary artery lesion. KD should be considered in the differential diagnosis of refractory EN in pediatric patients.

References

Oct 8, 1998·International Journal of Dermatology·B CribierE Grosshans
Jun 28, 2000·Clinical Rheumatology·D N PsychosH M Moutsopoulos
Jan 10, 2001·Journal of the American Academy of Dermatology·T KakourouP Nicolaidou
Oct 16, 2008·The Australasian Journal of Dermatology·Andrew Ming, Orli Wargon
Jun 2, 2011·Clinical Pediatrics·Zhaohua CaiYali Liu
Dec 4, 2015·Yonsei Medical Journal·Kyu Yeun Kim, Dong Soo Kim
Jun 28, 2016·Clinical and Experimental Immunology·T HaraS Yamasaki
Mar 31, 2017·Circulation·Brian W McCrindleUNKNOWN American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Di
Jun 22, 2017·Journal of Immunology Research·Ozlem OzbagcivanEmel Fetil

❮ Previous
Next ❯

Citations

Oct 26, 2021·Current Opinion in Rheumatology·Amira ElbendaryGaafar Ragab
Dec 2, 2021·Pediatrics in Review·Fatima I QuddusiDawn Marie R Davis

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Related Papers

Dermatology Practical & Conceptual
Ümran MusluYasemin Y Karabulut
Medicinski Glasnik : Official Publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina
Ahmad Saeed Azhar, Amjed Al-Attas
© 2022 Meta ULC. All rights reserved