Erythraemia due to haemoglobin San Diego

British Journal of Haematology
I ChanarinH Lehmann

Abstract

A 63-year-old man with erythraemia was found to have a high affinity haemoglobin which was subsequently identified as Hb San Diego beta 109 (G11) Val leads to Met, recently described in a Filipino family (Nute et al, 1974). The oxygen affinity of the haemolysates was increased approximately two-fold at pH values between 6.04 and 7.90. The n value was nearly normal (2.5-2.9) in the upper range of saturation (70-95% oxygenation) but was somewhat diminished (1.9-2.1) below this range. In vitro biosynthesis of globin by reticulocytes showed that there was balanced synthesis of alpha and beta chains (alpha:beta ratio = 1).

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Citations

Jun 1, 1977·British Journal of Haematology·A D Stephens
Dec 15, 1975·FEBS Letters·R FinneyW Walker
Jun 1, 1984·The British Journal of Venereal Diseases·F JerveE Hoftvedt
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Jan 19, 2021·Proceedings·Thein Hlaing Oo
May 20, 1976·Biochimica Et Biophysica Acta·R Casey, A Lang
Nov 26, 1976·Biochimica Et Biophysica Acta·K D JanyH H Kiltz

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