Erythrocytapheresis for Plasmodium falciparum infection complicated by cerebral malaria and hyperparasitemia

Journal of Clinical Apheresis
Y ZhangA J Indrikovs

Abstract

In malaria due to Plasmodium falciparum, life-threatening complications are in part related to the degree of parasitemia. Whole blood exchange and red blood cell exchange (RCE) have been used for the rapid removal of parasites from the circulation of patients with a high parasite load complicated by cerebral, pulmonary, and renal dysfunction. We have treated three 5-45-year-old patients with hyperparasitemia and end-organ dysfunction with red cell exchange by automated apheresis as an adjunct to specific anti-malarial chemotherapy. Parasitemia dropped more than 80% in all three patients immediately after the exchange, and all patients had an uneventful and full recovery. In combination with effective anti-malarial chemotherapy, apheresis RCE is a safe and rapid approach to treat complicated malaria due to P. falciparum.

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Citations

Oct 16, 2012·Wiener klinische Wochenschrift·Lorenz Auer-HackenbergMichael Ramharter
Jun 6, 2012·Hematology·Karolina S AkinosoglouCharalambos A Gogos
Feb 11, 2005·Infectious Disease Clinics of North America·Geoffrey Pasvol
Apr 17, 2015·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Himesh Barman
May 18, 2016·Analytical Chemistry·Rachel N DeraneyJeremy E Schonhorn
Apr 28, 2005·Journal of Intensive Care Medicine·Michael L Linenberger, Thomas H Price
Sep 20, 2017·Annals of Biomedical Engineering·A Blue MartinJames F Antaki
Feb 24, 2006·British Medical Bulletin·Geoffrey Pasvol
Oct 4, 2011·Journal of Clinical Apheresis·Phandee WatanaboonyongcharoenMark E Brecher
May 5, 2010·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Hae-Sun ChungDae-Won Kim
Jun 23, 2010·Journal of Clinical Apheresis·Zbigniew M SzczepiorkowskiUNKNOWN Apheresis Applications Committee of the American Society for Apheresis

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