Erythrocyte adducin: a structural regulator of the red blood cell membrane.

Transfusion clinique et biologique : journal de la Société française de transfusion sanguine
Taina Franco, P S Low

Abstract

Adducin is an alpha, beta heterotetramer that performs multiple important functions in the human erythrocyte membrane. First, adducin forms a bridge that connects the spectrin-actin junctional complex to band 3, the major membrane-spanning protein in the bilayer. Rupture of this bridge leads to membrane instability and spontaneous fragmentation. Second, adducin caps the fast growing (barbed) end of actin filaments, preventing the tetradecameric protofilaments from elongating into macroscopic F-actin microfilaments. Third, adducin stabilizes the association between actin and spectrin, assuring that the junctional complex remains intact during the mechanical distortions experienced by the circulating cell. And finally, adducin responds to stimuli that may be important in regulating the global properties of the cell, possibly including cation transport, cell morphology and membrane deformability. The text below summarizes the structural properties of adducin, its multiple functions in erythrocytes, and the consequences of engineered deletions of each of adducin subunits in transgenic mice.

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Nov 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Sriram SundaravelAmittha Wickrema
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Nov 15, 2012·The Journal of Biological Chemistry·Estela Puchulu-CampanellaPhilip S Low
Jun 4, 2018·Acta Biochimica Et Biophysica Sinica·Yajin ZhaoMan Hou
Sep 19, 2015·Ecology and Evolution·Veera NorrosOtso Ovaskainen

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