Erythrocyte Aggregation and Blood Viscosity is Similar in Homozygous Sickle Cell Disease Patients with and without Leg Ulcers

The International Journal of Angiology : Official Publication of the International College of Angiology, Inc
Andre S BowersDagogo J Pepple

Abstract

Background  There is no consensus regarding the role of red blood cell (RBC) aggregation in the pathogenesis of leg ulcers (LUs) in sickle cell disease (SCD). Objectives  We sought to evaluate whether the cross-sectional determination of RBC aggregation and hematological indices were associated with the presence of LU in homozygous SCD. Methods  Twenty-seven patients with LU and 23 with no history of ulceration were recruited into the study. A laser-assisted rotational red cell analyzer (LoRRca) was used in the determination of the aggregation index (AI), aggregation half-time ( t1/2 ), and the RBC aggregate strength (AMP). Hematological indices were determined using a CELL-DYN Ruby analyzer. Whole blood viscosity (WBV) and plasma viscosity (PV) were measured using a Vilastic bioprofiler. The data were presented as means ± standard deviation or median, interquartile range. Two-sample t -test was used to test for associations between the AIs, WBV, and PV in patients with and without LU. Statistical significance was taken as p  < 0.05. All analyses were conducted using Stata/SE v . 12.1 (StataCorp, College Station, TX). Results  The AI was comparable in the group with and without ulcers (68.6, 16.7 versus 67.7, 16.9; p  = 0.74); ...Continue Reading

Citations

Dec 24, 2019·Frontiers in Molecular Biosciences·Patrizia CaprariRoberta Risoluti
Jun 29, 2021·Frontiers in Bioengineering and Biotechnology·Andrew IskanderNiema Pahlevan
Jul 15, 2021·Advances in Skin & Wound Care·Tarun SahuRamanjan Sinha

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