The mammalian erythrocyte is an interesting model for studies of membrane aging. Experimental approaches to this problem involve, first of all, comparison of properties of erythrocytes separated by density because red blood cell age correlates with density in principle. Other approaches to study red cell membrane aging, such as hypertransfusion, are also discussed. A number of physical and chemical changes occur in erythrocytes with aging. Crucial to the elucidation of aging mechanisms is to determine which are primary and which are secondary. Immunoglobulin G binding triggers cellular removal and seems necessary for the recognition of senescent erythrocytes. Cellular deformability decreases while fragility to hemolytic factors generally increases and surface charge density does not alter. Perhaps more important are reactions of reactive oxygen species with membrane constituents and subsequent proteolysis. These are implicated as causative factors in red cell aging, immunoglobulin binding and recognition of senescent erythrocytes.
Determining the influence of storage time on the level of propofol in blood samples by means of chromatography
The influence of blood sample storage time on the propofol concentration in plasma and solid blood elements
Flow cytofluorimetric analysis of young and senescent human erythrocytes probed with lectins. Evidence that sialic acids control their life span
Nitrite, a reactive nitrogen species, protects human alpha-2-macroglobulin from halogenated oxidant, HOCl
Determination of the content of nonfilterable cells in erythrocyte suspensions as a function of the medium osmolality
In vivo survival of selected murine carrier red blood cells after separation by density gradients or aqueous polymer two-phase systems
Hydrogen-peroxide-induced heme degradation in red blood cells: the protective roles of catalase and glutathione peroxidase
Molecular mechanisms of erythrophagocytosis. Characterization of the senescent erythrocytes that are phagocytized by macrophages
Age-dependent acoustic and microelastic properties of red blood cells determined by vector contrast acoustic microscopy
Thalassaemic erythrocytes: cellular suicide arising from iron and glutathione-dependent oxidation reactions?
CD47 on experimentally senescent murine RBCs inhibits phagocytosis following Fcgamma receptor-mediated but not scavenger receptor-mediated recognition by macrophages
Heterogeneity of hypotonically loaded rat erythrocyte populations as detected by counter-current distribution in aqueous polymer two-phase systems
Surface and metabolic properties of microcytic and macrocytic human anaemic red blood cells detected in polymer aqueous two-phase systems
Surface properties of crosslinked erythrocytes as studied by counter-current distribution in aqueous polymer two-phase systems
pH-induced denaturation of spectrin changes the interaction of membrane proteins in erythrocyte ghosts. Biochemical and electron microscopic evidence
Stycholysin II, a cytolysin from the sea anemone Stichodactyla helianthus promotes higher hemolysis in aged red blood cells
The effects of superoxide dismutase knockout on the oxidative stress parameters and survival of mouse erythrocytes
Measuring cell surface area and deformability of individual human red blood cells over blood storage using quantitative phase imaging
MYH9-related disease mutations cause abnormal red blood cell morphology through increased myosin-actin binding at the membrane
Effect of bilirubin on erythrocyte shape and haemolysis, under hypotonic, aggregating or non-aggregating conditions, and correlation with cell age
Rapamycin mitigates erythrocyte membrane transport functions and oxidative stress during aging in rats
Assessment of transient changes in oxygen diffusion of single red blood cells using a microfluidic analytical platform.
Antioxidative system in the erythrocytes of preterm neonates with sepsis: the effects of vitamin E supplementation
Adhesion Molecules in Health and Disease
Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.