Erythrocyte and liver characteristics in low and high glutathione Finn sheep

Pharmacological Research Communications
A FaikK Pekka

Abstract

Selenium-uptake, glutathione peroxidase (GSH-Px), hepatic microsomal cytochrome P-450 and hepatic glutathione contents were studied in Finnsheep. The erythrocytes of low-GSH sheep had higher Selenium uptake and GSH-Px activity than did those in high-GSH animals. The low Se uptake in high-GSH sheep could be due to continuous pumping of Se from the cells into the erythrocytes, which reflects the active role of these cells, compared to those in low-GSH sheep. Significant differences in hepatic microsomal cytochrome P-450 content were found in the two groups of sheep. The greater activity among the low-GSH sheep suggests that they may have more active detoxification mechanisms than the high-GSH animals. The glutathione content in the liver was similar in both high and low-GSH sheep.

References

Nov 6, 1973·Biochemistry·O A LevanderD J Higgs
Feb 9, 1973·Science·J T RotruckW G Hoekstra
Jan 1, 1973·Acta Pharmacologica Et Toxicologica·M Sandholm
Jun 1, 1972·Australian Journal of Biological Sciences·N S AgarJ V Evans
Oct 20, 1967·Science·J E Smith, B I Osburn
Jan 1, 1983·Annual Review of Biochemistry·A Meister, M E Anderson

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Citations

Jan 1, 1987·Veterinary Research Communications·J ParantainenF Atroshi
Mar 1, 1994·Zentralblatt für Veterinärmedizin. Reihe A·A F RizzoE Elovaara

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