Erythrocyte antioxidant defense system in patients with chronic renal failure according to the hemodialysis conditions

Archives of Medical Research
Joanna StepniewskaDariusz Chlubek

Abstract

Patients suffering from chronic renal failure (CRF) are exposed to increased oxidative stress generated by uremic toxins, factors connected with hemodialysis, chronic inflammatory state, lack of vitamins A, E and selenium, advanced age, and parenteral iron administration. Their antioxidative system is inefficient. In erythrocytes, hexosemonophosphate (HMP) cycle does not assure an adequate amount of reductive equivalents (NADPH) necessary to restore reduced glutathione (GSH), an important free radical scavenger. Hemodialysis treatment also causes a large loss of glucose, which is the basic substrate for that metabolic pathway. The object of the research was to establish the influence of glucose present in dialysate on antioxidant defense system in red blood cells. A group of 51 patients undergoing regular hemodialysis using glucose (26 subjects, GL+ HD) or non-glucose fluid (25 subjects, GL- HD) was studied. The GSH concentration, glucose-6-phosphate dehydrogenase (G-6-P DH) and glutathione reductase (GSSG-R) activities were determined. Glucose concentration before and after the hemodialysis session was also measured. The activity of G-6-P DH was significantly higher in GL+ HD both before (p = 0.000) and after (p = 0.0002) the ...Continue Reading

References

Nov 1, 1992·Metabolism: Clinical and Experimental·M ToborekE Kopieczna-Grzebieniak
Nov 1, 1970·Journal of Clinical Pathology·M L Salkie, E Simpson
Jan 1, 1995·Free Radical Biology & Medicine·T GruneW G Siems
Jul 1, 1994·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·M Taccone-GalluciC U Casciani
Mar 1, 1996·Biological Trace Element Research·T H LinJ G Juang
Oct 1, 1996·Kidney International·M DaschnerM Leichsenring
Jan 1, 1996·Free Radical Biology & Medicine·I Ceballos-PicotB Descamps-Latscha
Sep 1, 1996·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·S BiasioliD Giavarina
Jul 1, 1997·Biological Trace Element Research·C K ChenT H Lin
Jul 2, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter Stenvinkel, Peter Bárány
Jun 17, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesco LocatelliCarmine Zoccali
Aug 19, 1955·Science·I KRIMSKY, E RACKER
Nov 11, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter Stenvinkel

❮ Previous
Next ❯

Citations

Dec 1, 2011·International Urology and Nephrology·Barbara DołęgowskaMaria Olszewska
Nov 21, 2012·PloS One·Maxim N PetrovSergei M Danilov
Nov 26, 2015·Journal of Inherited Metabolic Disease·A S DavisonL R Ranganath
Jan 24, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Patrick Steven TuckerMichael Ian Kingsley
Apr 14, 2015·Oxidative Medicine and Cellular Longevity·Anna Pieniazek, Krzysztof Gwozdzinski
Aug 27, 2016·Oxidative Medicine and Cellular Longevity·Konstantina P PoulianitiChristina Karatzaferi
Dec 5, 2009·Critical Reviews in Clinical Laboratory Sciences·Daniela GiustariniRanieri Rossi
Dec 14, 2018·Nutrients·Dina A TallmanPramod Khosla

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.