PMID: 7022473Jan 1, 1981Paper

Erythrocyte calcium abnormalities in sickle cell disease

Progress in Clinical and Biological Research
R P HebbelJ W Eaton

Abstract

During a relatively brief tenure in the circulation, sickle erythrocytes may become dehydrated and irreversibly deformed and acquire extensive membrane damage. Abnormally high intracellular calcium concentrations may contribute to these abnormalities, as evidenced by the fact that many of them may be reproduced through ionophoric leading of normal red cells with small amounts of calcium. Sickle erythrocytes have another, possibly related, abnormality; they adhere to cultured vascular endothelium, perhaps due to the disordered (i.e., clumped) negative surface charge present on many Hb SS red cells. This endothelial adherence may have pathophysiologic significance, in that the attendant slowing of erythrocyte circulation may help initiate and propagate vascular occlusions.

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.