Erythrocyte-Derived Nanoparticles as a Theranostic Agent for Near-Infrared Fluorescence Imaging and Thrombolysis of Blood Clots

Macromolecular Bioscience
Raviraj VankayalaBahman Anvari

Abstract

Ischemic stroke occurs when a blood clot obstructs or narrows the arteries that supply blood to the brain. Currently, tissue plasminogen activator (tPA), a thrombolytic agent, is the only United States Food and Drug Administration (FDA)-approved pharmacologic treatment for ischemic stroke. Despite its effective usage, the major limitation of tPA that stems from its short half-life in plasma (≈5 min) is the potential for increased risk of hemorrhagic complications. To circumvent these limitations, herein, the first proof-of-principle demonstration of a theranostic nanoconstruct system derived from erythrocytes doped with the FDA-approved near-infrared (NIR) imaging agent, indocyanine green, and surface-functionalized with tPA is reported. Using a clot model, the dual functionality of these nanoconstructs in NIR fluorescence imaging and clot lysis is demonstrated. These biomimetic theranostic nanoconstructs may ultimately be effective in imaging and treatment of blood clots involved in ischemic stroke.

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Citations

Mar 7, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Joon Ho ParkLiangfang Zhang
Aug 21, 2019·Journal of Biomedical Optics·Taylor HanleyBahman Anvari
May 14, 2020·Pharmaceutics·Bridget E Bax
Sep 19, 2020·Advanced Drug Delivery Reviews·Flávia CastroBruno Sarmento
Aug 21, 2020·Biomaterials·Alina ZenychCédric Chauvierre
Jun 3, 2021·Pharmaceutics·Clara Correa-PazFrancisco Campos
Jun 3, 2021·Biomolecules·Taylor HanleyBahman Anvari
Jun 10, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Maxim A ZakharzhevskiiVladimir V Vinogradov

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