Erythrocyte fatty acids and prostate cancer risk: a comparison of methods.

Prostaglandins, Leukotrienes, and Essential Fatty Acids
J ShannonI B King

Abstract

The role of fatty acids (FA) in prostate carcinogenesis is unclear. Interest in the inter-relationship among different types of FA has resulted in new analytic approaches to FA and their role in cancer development. We evaluated the association between erythrocyte FA and prostate cancer in 127 prostate cancer patients and 183 screen negative controls. We present three approaches to the analyses of the FA and prostate cancer association; (1) individual or common groups of FA, (2) biologically meaningful FA ratios and (3) principal components analysis. Monounsaturated FA and the alpha-linolenic:eicosapentaenoic ratio were associated with reduced risk of prostate cancer. However, Factor 1, which was strongly correlated with some long chain saturated FA, was associated with an increased risk of prostate cancer. We provide an example of modeling FA and their inter-relationships on the risk of prostate cancer. Comparing three approaches suggests the importance of considering the impact of the entire fatty acid profile in disease prevention.

References

Jul 15, 1998·American Journal of Epidemiology·M E MartínezL Sechrest
Jun 9, 2001·The Prostate·L M NewcomerJ L Stanford
Mar 14, 2002·Current Opinion in Lipidology·Donald B Jump
Apr 14, 2004·Critical Reviews in Clinical Laboratory Sciences·Donald B Jump
Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·Stacy MoorePeter S Nelson
Jul 15, 2005·American Journal of Epidemiology·Jackilen ShannonPaige E Farris
Jan 21, 2006·Cancer Causes & Control : CCC·June M ChanEdward L Giovannucci
Jan 26, 2006·JAMA : the Journal of the American Medical Association·Catherine H MacLeanSally C Morton
Mar 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Philippe BougnouxCharles Couet
Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Naoko KobayashiWilliam J Aronson
Dec 13, 2006·The Journal of Urology·Chad R RitchCharles B Brendler
Apr 7, 2007·The American Journal of Clinical Nutrition·Jackilen ShannonDavid B Thomas
Jun 23, 2007·The Journal of Nutrition·Marian L NeuhouserGary Goodman
Jun 23, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jorge E ChavarroJing Ma
Nov 29, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Benno KrachlerBernt Lindahl
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Matthias P Wymann, Roger Schneiter
Oct 22, 2008·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Philippe BougnouxCharles Couet
Dec 6, 2008·The American Journal of Clinical Nutrition·Jackilen ShannonDavid B Thomas
Dec 9, 2008·Journal of Molecular Endocrinology·Tuulikki Seppänen-Laakso, Matej Oresic
Feb 26, 2009·International Immunopharmacology·C A C Hyde, S Missailidis
Mar 27, 2009·The American Journal of Clinical Nutrition·Joel A SimonStephen Bent
Oct 20, 2009·Nutrition and Cancer·Jackilen ShannonMark Garzotto
Oct 24, 2009·Clinical Chemistry·Matthew T Flowers

❮ Previous
Next ❯

Citations

May 25, 2012·The British Journal of Nutrition·Mariette Gerber
Jun 15, 2013·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Michael E ChuaMarcelino L Morales
Jan 8, 2014·Current Atherosclerosis Reports·Hassan FaresRichard V Milani
Apr 17, 2013·Prostate Cancer·Mishell Kris Sorongon-LegaspiMarcelino Morales
Jul 19, 2011·International Journal of Food Sciences and Nutrition·Verónica M Heinze, Adriana B Actis
Nov 26, 2015·Journal of the American College of Nutrition·Michael T DinwiddieRachel E Patzer
Jun 18, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Clemens von Schacky
May 16, 2014·Cancer Prevention Research·Xavier MoreelVincent Fradet
Nov 2, 2021·Medicinal Research Reviews·Prema K AgarwalaShobhna Kapoor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Bollettino della Società italiana di biologia sperimentale
R Rondinone
Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
Federico GuerraAlessandro Capucci
Journal of Health Care for the Poor and Underserved
Flora A UkoliDerrick J Beech
© 2021 Meta ULC. All rights reserved