PMID: 6108447Dec 13, 1980Paper

Erythrocyte glyceraldehyde-reductase levels in diabetics with retinopathy and cataract

Lancet
M J CrabbeH Cheng

Abstract

The activity levels of glyceraldehyde reductase, an aldose-reductase-like enzyme present in the erythrocyte, were determined in 104 subjects, who were divided into five groups--diabetics with retinopathy and cataract, diabetics with retinopathy and no cataract, diabetics with no retinopathy and no cataract, non-diabetics with senile cataract, and non-diabetic normal controls. Diabetics with retinopathy and cataract had significantly higher mean enzyme activity levels than normal control subjects (2.5 fold increase, p < 0.001); so had diabetics with retinopathy but no cataract (2 fold, p < 0.01) and patients with senile cataract (1.5 fold, p < 0.05). Juvenile diabetics had a significantly higher enzyme level than maturity onset diabetics. There was no significant difference in glyceraldehyde reductase between normal controls and diabetics without retinopathy or cataract, and no significant difference in polyol-dehydrogenase activity levels between any group studied. Enzyme activity did not correlate with age or glycosylated haemoglobin (HbA1c) levels. The increase in levels of erythrocyte glyceraldehyde reductase were due to increased amounts of active enzyme, rather than to elaboration of new kinetic pathways.

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Citations

Jan 1, 1995·International Journal of Biometeorology·Y OhtsukaY Agishi
Jun 1, 1996·Diabetes Research and Clinical Practice·E Kicic, T N Palmer
Jun 1, 1997·Diabetes Research and Clinical Practice·T ItoY Omori
Aug 8, 1998·Progress in Retinal and Eye Research·M J Crabbe, D Goode
Dec 1, 1994·Acta Paediatrica Japonica; Overseas Edition·Y IshidaK Konishi
Apr 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·Y HamadaP Raskin
Oct 1, 1983·The British Journal of Ophthalmology·M J CrabbeJ Howard-Williams
Sep 14, 2007·American Journal of Nephrology·Yukiko HasuikeTakeshi Nakanishi
Jan 1, 1989·Analytical Biochemistry·C E Grimshaw, E J Mathur

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