Abstract
The activity levels of glyceraldehyde reductase, an aldose-reductase-like enzyme present in the erythrocyte, were determined in 104 subjects, who were divided into five groups--diabetics with retinopathy and cataract, diabetics with retinopathy and no cataract, diabetics with no retinopathy and no cataract, non-diabetics with senile cataract, and non-diabetic normal controls. Diabetics with retinopathy and cataract had significantly higher mean enzyme activity levels than normal control subjects (2.5 fold increase, p < 0.001); so had diabetics with retinopathy but no cataract (2 fold, p < 0.01) and patients with senile cataract (1.5 fold, p < 0.05). Juvenile diabetics had a significantly higher enzyme level than maturity onset diabetics. There was no significant difference in glyceraldehyde reductase between normal controls and diabetics without retinopathy or cataract, and no significant difference in polyol-dehydrogenase activity levels between any group studied. Enzyme activity did not correlate with age or glycosylated haemoglobin (HbA1c) levels. The increase in levels of erythrocyte glyceraldehyde reductase were due to increased amounts of active enzyme, rather than to elaboration of new kinetic pathways.
References
Apr 1, 1979·Metabolism: Clinical and Experimental·J H KinoshitaL O Merola
Dec 1, 1979·Clinical Biochemistry·M J Crabbe, A B Halder
Sep 1, 1976·The British Journal of Nutrition·J C HuttonF C Hollows
Jan 14, 1977·Science·S D VarmaJ H Kinoshita
Jan 1, 1977·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C N CorderJ Sharma
Jun 15, 1979·Experientia·N S Agar
Nov 16, 1978·Nature·D AllanR H Michell
Jan 1, 1976·Experimental Eye Research·J J Harding, K J Dilley
Aug 19, 1976·The New England Journal of Medicine·R J KoenigA Cerami
Nov 27, 1975·Nature·D Allan, R H Michell
Dec 29, 1974·Biochimica Et Biophysica Acta·M A Attwood, C C Doughty
Nov 1, 1974·Diabetes·M J Albrink
Sep 10, 1969·Biochemical and Biophysical Research Communications·R S Clements, A I Winegrad
Jun 28, 1972·Biochemical and Biophysical Research Communications·R S Clements, A I Winegrad
May 1, 1974·The Journal of Clinical Investigation·E Beutler, E Guinto
May 1, 1971·Experimental Eye Research·R Van Heyningen
Oct 1, 1969·Experimental Eye Research·M TestaS Calabrò
Dec 1, 1967·Journal of Neurochemistry·G I Moonsammy, M A Stewart
Apr 1, 1980·Biochemical Society Transactions·M J Crabbe, A B Halder
Mar 1, 1980·Diabetologia·L C Baxter, P J Schofield
Apr 1, 1980·Diabetologia·D WeilandG M Reaven
Jun 1, 1962·Experimental Eye Research·J H KINOSHITAE DIKMAK
Jun 1, 1964·Experimental Eye Research·A PIRIE, R VANHEYNINGEN
Apr 19, 2013·Frontiers in Pharmacology·Eric C BeyerViviana M Berthoud
Citations
Mar 1, 1994·Diabetologia·C NishimuraT Tanimoto
Jan 1, 1995·International Journal of Biometeorology·Y OhtsukaY Agishi
Mar 28, 1986·Biochimica Et Biophysica Acta·S K SrivastavaB Das
Jun 1, 1996·Diabetes Research and Clinical Practice·E Kicic, T N Palmer
Jun 1, 1997·Diabetes Research and Clinical Practice·T ItoY Omori
Aug 8, 1998·Progress in Retinal and Eye Research·M J Crabbe, D Goode
Dec 1, 1994·Acta Paediatrica Japonica; Overseas Edition·Y IshidaK Konishi
Apr 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·Y HamadaP Raskin
Oct 1, 1983·The British Journal of Ophthalmology·M J CrabbeJ Howard-Williams
Sep 14, 2007·American Journal of Nephrology·Yukiko HasuikeTakeshi Nakanishi
Jan 1, 1989·Analytical Biochemistry·C E Grimshaw, E J Mathur