Erythrocyte-mediated delivery of dexamethasone in patients with mild-to-moderate ulcerative colitis, refractory to mesalamine: a randomized, controlled study

The American Journal of Gastroenterology
Fabrizio BossaVito Annese

Abstract

Nearly 25% of patients with ulcerative colitis (UC) requiring steroids therapy become steroid-dependent after 1 yr, and virtually all develop steroid-related adverse events. We planned a controlled study to investigate the efficacy and safety of dexamethasone 21-P (Dex 21-P) encapsulated into erythrocytes (DEE). Forty patients with mild-to-moderate UC, refractory to mesalamine, were randomly assigned to one of the following three treatments: two DEE infusions 14 days apart (group A, N = 20), oral prednisolone (0.5 mg/kg for 14 days followed by a 6 mg/weekly tapering (group B, N = 10), and sham infusions (group C, N = 10). The clinical, biochemical, and endoscopic parameters were monitored at inclusion and after 8 wk. In group A, a mean dose of 9.9 +/- 4.1 mg Dex 21-P was loaded into autologous erythrocytes at each infusion. At 8 wk, 15 patients in group A (75%), 8 in group B (80%), and 1 in group C (10%, P < 0.001 vs A and B) were in clinical and endoscopic remission. When compared with the baseline values, C-reactive protein (CRP) dropped in groups A (1.6 mg/dL vs 0.4 mg/dL, P= 0.006) and B (1.0 vs 0.5, P= 0.02), but not in group C. No steroid-related adverse events were apparent in the patient treated with DEE, compared with ...Continue Reading

References

Jan 1, 1978·Scandinavian Journal of Gastroenterology·J Powell-TuckJ E Lennard-Jones
Jan 1, 1992·Advances in Experimental Medicine and Biology·J F Hoffman
Mar 30, 2001·Biotechnology and Applied Biochemistry·L RossiM Magnani
Feb 22, 2002·The Medical Letter on Drugs and Therapeutics
May 11, 2002·The American Journal of Gastroenterology·Yu-Xiao Yang, Gary R Lichtenstein
Aug 9, 2002·The New England Journal of Medicine·Daniel K Podolsky
Jan 11, 1964·British Medical Journal·J H BARONJ E LENNARD-JONES
Jul 6, 2004·The American Journal of Gastroenterology·Asher KornbluthUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Jun 3, 2005·The American Journal of Gastroenterology·Vito AnneseMauro Magnani
Aug 5, 2006·Journal of Pharmaceutical and Biomedical Analysis·Gianluca DamonteUmberto Benatti

❮ Previous
Next ❯

Citations

Jul 27, 2012·Therapeutic Delivery·Carmen Gutiérrez MillánJosé M Lanao
Feb 20, 2014·Expert Opinion on Drug Delivery·Mauro Magnani, Luigia Rossi
Jun 10, 2014·Expert Opinion on Drug Delivery·Manisha BhateriaRabi Sankar Bhatta
Mar 3, 2010·Expert Opinion on Drug Delivery·Vladimir R Muzykantov
May 19, 2009·Expert Opinion on Pharmacotherapy·Fabrizio BossaVito Annese
Mar 4, 2009·Journal of Drug Targeting·Alessandra FraternaleMauro Magnani
Aug 7, 2009·Expert Opinion on Emerging Drugs·Luca PastorelliMaurizio Vecchi
Aug 1, 2015·Therapeutic Delivery·Carlos H VillaVladimir R Muzykantov
Apr 16, 2011·The American Journal of Gastroenterology·Nicholas J TalleyUNKNOWN American College of Gastroenterology IBD Task Force
Mar 17, 2011·The American Journal of Gastroenterology·Alexander C FordPaul Moayyedi
Oct 6, 2011·Nature Reviews. Gastroenterology & Hepatology·Kirstin M Taylor, Peter M Irving
Nov 28, 2012·Advanced Healthcare Materials·Che-Ming J HuLiangfang Zhang
Oct 5, 2018·Expert Review of Gastroenterology & Hepatology·Belinda Jackson, Peter De Cruz
Nov 12, 2009·Current Gastroenterology Reports·Miles P SparrowStephen B Hanauer
Jul 19, 2011·IUBMB Life·Sara BiagiottiMauro Magnani
Mar 20, 2014·Alimentary Pharmacology & Therapeutics·S DaneseL Peyrin-Biroulet
May 24, 2020·Acta Biochimica Et Biophysica Sinica·Guangmeng XuLihua Dong
Dec 2, 2017·Advanced Healthcare Materials·Alexander S TiminGleb B Sukhorukov
Jul 7, 2017·Orphanet Journal of Rare Diseases·Michele MenottaMauro Magnani
Nov 1, 2017·World Journal of Gastroenterology : WJG·Karen Dubois-CamachoMarcela A Hermoso
Jul 27, 2017·Molecular and Cellular Biochemistry·Michele MenottaMauro Magnani
Aug 14, 2015·World Journal of Gastroenterology : WJG·Satoshi TanidaTakashi Joh
Mar 22, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Luigia RossiMauro Magnani
Sep 19, 2020·Advanced Drug Delivery Reviews·Flávia CastroBruno Sarmento
May 2, 2021·Colloids and Surfaces. B, Biointerfaces·Chen WangBinbin Chen
Apr 1, 2021·Annual Review of Biomedical Engineering·Jacob S BrennerVladimir R Muzykantov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.