Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study.

Breast Cancer Research : BCR
Emma E McGeeA Heather Eliassen

Abstract

Previous studies of fatty acids and breast cancer risk have shown mixed results, which may be due in part to tumor heterogeneity. Prior research has also illustrated an important role of specific fatty acids in immune regulation, T cell function, and inflammation, indicating that the effects of specific fatty acids on breast cancer risk may vary by tumor expression of immuno-inflammatory markers. We therefore aimed to evaluate the relationships between prediagnostic erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers (CD4, CD8, CD20, CD163, COX-2) and fatty acid synthase (FAS). We conducted a matched case-control study nested within the Nurses' Health Study II (n = 235 cases and 235 controls). Blood samples were collected from 1996 to 1999. Tumor tissue blocks were collected for cases diagnosed after blood collection and through 2006. Unconditional nominal polytomous logistic regression adjusted for matching factors and potential confounders was used to assess whether associations between fatty acids and breast cancer risk varied by tumor expression subtype, ascertained via immunohistochemistry. Odds ratios (OR) and 95% confidence intervals (CI) were estimated separa...Continue Reading

References

May 15, 1990·International Journal of Cancer. Journal International Du Cancer·D G ZaridzeD M Maximovitch
May 1, 1989·Statistics in Medicine·S Durrleman, R Simon
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L J VattenE Jellum
Oct 16, 1999·International Journal of Cancer. Journal International Du Cancer·V ChajèsE Riboli
Jul 19, 2001·Journal of the National Cancer Institute·V PalaF Berrino
Mar 4, 2003·The Journal of Nutrition·Lenore Arab
Jul 26, 2003·Nutrition and Cancer·Harri RissanenTimo Hakulinen
May 26, 2004·The American Journal of Clinical Nutrition·David J BaerRussell P Tracy
Oct 5, 2006·Journal of the National Cancer Institute·A Heather EliassenSusan E Hankinson
Mar 14, 2007·International Journal of Cancer. Journal International Du Cancer·Kiyonori KurikiKazuo Tajima
Apr 7, 2007·The American Journal of Clinical Nutrition·Jackilen ShannonDavid B Thomas
Sep 21, 2007·Nature Reviews. Cancer·Javier A Menendez, Ruth Lupu
Mar 11, 2008·The American Journal of Clinical Nutrition·Annie Motard-BélangerBenoît Lamarche
Apr 9, 2008·American Journal of Epidemiology·Véronique ChajèsFrançoise Clavel-Chapelon
Aug 7, 2008·Breast Cancer Research : BCR·Rulla M TamimiLaura C Collins
Mar 25, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Joanne KotsopoulosA Heather Eliassen
Jul 6, 2011·Breast Cancer Research and Treatment·Michelle D HolmesRulla M Tamimi
Aug 11, 2011·Breast Cancer Research and Treatment·Rulla M TamimiLaura C Collins
Feb 14, 2012·Prostaglandins & Other Lipid Mediators·Karsten H WeylandtBertram Wiedenmann
Apr 21, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Harmony F Turk, Robert S Chapkin
Mar 19, 2013·Breast Cancer Research : BCR·Renée T FortnerSusan E Hankinson
Jun 25, 2013·Cell Metabolism·Erin CurrieRobert V Farese
Sep 13, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R SalgadoUNKNOWN International TILs Working Group 2014
Jan 17, 2015·Trends in Immunology·Matthias LochnerTim Sparwasser
May 6, 2015·Breast Cancer Research : BCR·Carol J FabianStephen D Hursting
Aug 12, 2015·The Journal of Experimental Medicine·Michael D BuckErika L Pearce
Dec 2, 2015·Statistics in Medicine·Molin WangShuji Ogino

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Methods Mentioned

BETA
blood collection

Key Resources (RRID) Mentioned

AB_10078980
AB_10984436

Software Mentioned

Definiens Tissue Studio
Aperio

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