Erythrocyte membrane lipids and serum selenium in post-viral and alcoholic cirrhosis

Clinica Chimica Acta; International Journal of Clinical Chemistry
P GuariniR Corrocher

Abstract

Erythrocyte-membrane fatty acid composition and cholesterol content were evaluated along with serum selenium in 33 patients with liver cirrhosis and in 40 normal subjects. Thirteen patients were suffering from post-viral (group V) and 20 from alcoholic (group A) cirrhosis. The aim of the study was to elucidate whether membrane lipid abnormalities in cirrhosis were linked to the aetiology of the disease or whether they were the results of the cirrhotic process itself. The patients presented a significant increase in membrane cholesterol, palmitic acid (C16:0) and saturated fatty acids (SFA), and a decrease in polyunsaturated fatty acids (PUFA) and polyunsaturated/saturated fatty acids ratio (P/S) compared with the control group. Serum selenium levels were significantly reduced. When patients were subdivided according to aetiology, the alcoholic patients showed greater lipid composition abnormalities than the viral cirrhotics (higher levels of SFA and lower PUFA and P/S), while pathologic palmitic acid, membrane cholesterol and serum selenium values were confirmed in both groups of patients. In conclusion, low serum selenium and a series of erythrocytes membrane lipid composition abnormalities would appear to be features peculiar...Continue Reading

References

Jun 16, 1978·Biochimica Et Biophysica Acta·J S Owen, N McIntyre
Oct 30, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·D GirelliR Corrocher
Mar 1, 1992·Journal of Hepatology·P J Thuluvath, D R Triger
Sep 1, 1992·Metabolism: Clinical and Experimental·J GonzálezF Sánchez de Medina
May 31, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·T MacchiaA Cantafora
Dec 1, 1990·The American Journal of Gastroenterology·E CabréF Sánchez-Medina
Feb 1, 1989·Clinical Biochemistry·S W French
Jun 30, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·M CasarilR Corrocher
Jul 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A SchullerA M Municio
Sep 1, 1988·Scandinavian Journal of Clinical and Laboratory Investigation·T A Hagve
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S B JohnsonR T Holman
Feb 15, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·M R ClemensH D Waller
Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Oct 16, 1980·The New England Journal of Medicine·P BalckeE Deutsch
Aug 1, 1994·The American Journal of Clinical Nutrition·E LecomteY Artur
Oct 1, 1994·The American Journal of Clinical Nutrition·O OlivieriS Ferrari

❮ Previous
Next ❯

Citations

May 17, 2000·The Science of the Total Environment·M Navarro-Alarcón, M C López-Martínez
Jul 23, 2013·Journal of Clinical Biochemistry and Nutrition·Danijela Ristić-MedićMarija Glibetić
Mar 1, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Beáta Éva PetrovskiZoltán Vokó
Mar 3, 2009·Acta Biomaterialia·Lorenzo AulisaJeffrey D Hartgerink
Oct 19, 2004·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Rudy Van CauwenberghHendrik Deelstra
Nov 3, 2004·Journal of Hepatology·Marie-Astrid PiquetXavier M Leverve
Aug 16, 2005·Archives of Medical Research·Serdar OztezcanMüjdat Uysal
Jan 15, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Themistoklis VassiliadisNikolaos Evgenidis
Feb 28, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fabiola RusoloSusan Costantini
Dec 10, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·E Cabré, M A Gassull
Jan 11, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·E Cabré, M A Gassull
Aug 1, 2012·Oncology Letters·Michele DI StasioSusan Costantini
Aug 12, 2020·Alimentary Pharmacology & Therapeutics·Thomas MouillotUNKNOWN CIRCE Study Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.