PMID: 8021475Mar 1, 1994Paper

Erythrocyte membrane microviscosity and blood pressure in rats with salt-induced and spontaneous hypertension

Journal of Hypertension
J KunesM A Devynck


To study membrane viscosity in various rat strains with genetic forms of experimental hypertension. The relationship between blood pressure and membrane dynamics was investigated in erythrocytes from three different rat strains with experimental hypertension, namely two models of salt-induced hypertension (Sabra and Dahl rats) and Lyon hypertensive rats with spontaneous hypertension. Membrane microviscosity was evaluated by diphenylhexatriene and trimethylamino-diphenylhexatriene fluorescence steady-state anisotropy. There were no significant differences among particular experimental groups in trimethylamino-diphenylhexatriene anisotropy that reflect microviscosity changes at the water-lipid interface of the external membrane leaflet. In contrast, the diphenylhexatriene anisotropy, which is related to the core membrane microviscosity, was significantly reduced in the Dahl salt-sensitive rats (irrespective of salt intake level) and in the Sabra hypertension-prone rats with developed salt hypertension. Erythrocyte membranes of Lyon hypertensive rats also had lower values of diphenylhexatriene anisotropy than the respective normotensive controls but this difference was not statistically significant. Systolic (and often also diasto...Continue Reading


Jun 21, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·K TsudaY Masuyama
Aug 1, 2019·American Journal of Physiology. Renal Physiology·Robert L RepettiRajeev Rohatgi

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