Erythrocyte Sedimentation Rate Combined With the Probe-to-Bone Test for Fast and Early Diagnosis of Diabetic Foot Osteomyelitis.

The International Journal of Lower Extremity Wounds
Jun XuPenghua Wang

Abstract

This study aimed to investigate the erythrocyte sedimentation rate (ESR) optimal cutoff point in Chinese patients with diabetic foot osteomyelitis (DFO) and to evaluate the screening value of ESR combined with probe-to-bone (PTB) test for a fast diagnosis of DFO in early stage. A total of 204 diabetic inpatients with foot infection were tested for white blood cell count, neutrophil %, C reactive protein, and ESR at admission within 24 hours. All patients were performed PTB test. Patients with DFO (111) were confirmed by bone biopsy, the other patients (86) had only soft tissue infection. Although white blood cell count, neutrophil %, C-reactive protein, and ESR were different between the 2 groups, only area under curve of ESR was 0.832, with the value as a diagnostic indicator. The best cut point of ESR was >43 mm/h; the sensitivity, specificity, positive predictive value (+PV), and negative predictive value (-PV) were 82.9%, 70.5%, 0.78, and 0.77, respectively. ESR combined with PTB test (serial test), the sensitivity, specificity, +PV, -PV, positive likelihood ratio (+LR), and negative LR (-LR) were 63.56%, 98%, 0.97, 0.67, 31.75, and 0.37, respectively. ESR combined with PTB test (parallel test), the sensitivity, specificity...Continue Reading

References

Oct 3, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Marius HorgerRoland Bares
Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin A LipskyUNKNOWN Infectious Diseases Society of America
May 17, 2005·Radiologic Clinics of North America·Deep S ChathaMark E Schweitzer
Nov 18, 2005·Lancet·Andrew J M BoultonJan Apelqvist
May 30, 2006·Diabetes Care·Lawrence A LaveryBenjamin A Lipsky
Jan 24, 2007·Archives of Internal Medicine·Alok KapoorDavid T Felson
Feb 21, 2008·JAMA : the Journal of the American Medical Association·Sonia ButaliaOphyr Mourad
Apr 30, 2008·Diabetes/metabolism Research and Reviews·A R BerendtG D Valk
Jul 10, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marie T DinhNasia Safdar
Jan 2, 2009·Diabetes Research and Clinical Practice·Lawrence A LaveryBenjamin A Lipsky
Jan 12, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·J Aragón-SánchezJ L Lázaro-Martínez
Jun 11, 2011·Diabetes Research and Clinical Practice·Mesut MutluoğluSenol Yildiz
Feb 1, 2012·Diabetes/metabolism Research and Reviews·B A LipskyUNKNOWN International Working Group on Diabetic Foot
May 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin A Lipsky Infectious Diseases Society of America
Feb 7, 2013·Scandinavian Journal of Infectious Diseases·Mesut MutluogluBenjamin A Lipsky
May 9, 2013·BioMed Research International·Elena TsourdiStefan R Bornstein
Jul 15, 2015·Current Diabetes Reviews·Suzanne Aura Victoria van AstenLawrence Alfred Lavery
Jul 3, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kenrick LamLawrence A Lavery

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Citations

Dec 4, 2020·Journal of Clinical Medicine·Aroa Tardáguila-GarcíaJosé Luis Lázaro-Martínez
Mar 18, 2021·Journal of Diabetes Research·Yaqi WangYan Su
Aug 6, 2021·The International Journal of Lower Extremity Wounds·Nikolaos PapanasKittipan Rerkasem

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Methods Mentioned

BETA
ESR
X-ray
biopsy
biopsies
amputation
amputations

Software Mentioned

SPSS

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