Erythrocyte sodium transport, intraplatelet pH, and calcium concentration in salt-sensitive hypertension

Hypertension
M M LluchA Urbano-Márquez

Abstract

We evaluated changes in erythrocyte sodium transport systems, platelet pH, and calcium concentration induced by low and high salt intakes in a group of 50 essential hypertensive patients classified on the basis of their salt sensitivity. Patients received a standard diet with 20 mmol NaCl daily for 2 weeks supplemented in a single-blind fashion by placebo tablets the first 7 days and NaCl tablets the following 7 days. Salt sensitivity, defined as a significant rise (P <.05) in 24-hour mean blood pressure obtained by ambulatory blood pressure monitoring, was diagnosed in 22 (44%) patients. The remaining 28 (56%) were considered to have salt-resistant hypertension. In the entire group of hypertensive patients, high salt intake promoted a significant increase (P <.05) in the maximal rate of erythrocyte NA(+)-Li(+) countertransport (from 271 +/- 19 to 327 +/- 18 microM/(L cells/h) and of the Na(+)-dependent HCO3(-)-CL(-) exchanger (from 946 +/- 58 to 1237 +/- 92 microM/L cells/h) as well as in platelet pH (from 7.15+/-0 0.01 to 7.19+/-0.02 and calcium concentration (from 49+/-2 to 57 +/-2 nmol/L). Depending on salt sensitivity, high salt intake promoted opposing changes in some of the sodium transport systems studied. Salt-sensitiv...Continue Reading

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Citations

Feb 1, 2002·The Journal of Clinical Hypertension·Ernesto Bragulat, Alejandro de la Sierra
Feb 5, 2002·Annual Review of Physiology·Eric Delpire, David B Mount
Mar 5, 2002·Journal of Hypertension·Cristina SierraAntonio Coca
Aug 5, 2015·Electrolyte & Blood Pressure : E & BP·Hoon Young ChoiSung Kyu Ha
Feb 8, 2006·American Journal of Hypertension·Maria LarrousseAlejandro de La Sierra
Mar 10, 1999·The American Journal of Physiology·S N OrlovP Hamet

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