journal cover

Erythrocyte surface: novel determinant of drug susceptibility in rodent malaria

Antimicrobial Agents and Chemotherapy

Aug 1, 1978

C D FitchR Chevli

PMID: 358916

Abstract

To study the role of the erythrocyte membrane in the process of chloroquine accumulation, surface polypeptides were digested with a nonspecific protease from Streptomyces griseus. This treatment activated a saturable process of chloroquine accumulation with an affinity and a specificity...read more

Mentioned in this Paper

Plasmodium berghei
Antibiotic Resistance, Microbial
Cinchona pubescens
Alb
Sigmoid Colon
Cold Temperature
Peptide Hydrolases
Endopeptidases
Digests
Glucose, (beta-D)-Isomer
Paper Details
References
  • References12
  • Citations18
12
  • References12
  • Citations18
12

Similar Papers Found In These Feeds

Plasmodium Falciparum

Malaria remains a major cause of morbidity and mortality in the tropics, with the parasite Plasmodium falciparum responsible for the majority of the disease burden. Discover the latest research on Plasmodium falciparum.

Malaria Vaccines

Research for development of a malaria vaccine is currently underway to find an effective modality to control and eliminate the transmission of malaria. To date, no vaccine has been found to be efficacious in fighting against malaria. Here is the latest research on malaria vaccines.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Vitamin K Carboxylase & Antibiotics

Vitamin K-dependent carboxylases generate gamma-carboxyglutamic acids with malonate moieties by modifying glutamate residues in vitamin K-dependent proteins. This feed focuses on cellular mechanisms regulated by vitamin K-dependent carboxylases.

Malaria

Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. Discover the latest research on malaria here,

Oxygenation & Hydroxylation

Oxygenation is a chemical production that introduces oxygen atom into an organic compound. Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Cytochrome P450 (CYP) enzymes are expressed mainly in the liver and are active in mono-oxygenation and hydroxylation of various xenobiotics, including drugs and alcohols, as well as that of endogenous compounds such as steroids, bile acids, prostaglandins, leukotrienes and biogenic amines. Here is the latest research.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Allergy And Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Related Papers

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology

Molecular karyotypes: separating chromosomes on gels

BioEssays : News and Reviews in Molecular, Cellular and Developmental BiologyDecember 1, 1985
L M Corcoran
Life Sciences

Chloroquine accumulation by erythrocytes: a latent capability

Life SciencesJune 16, 1974
C D FitchY Gonzalez
© 2020 Meta ULC. All rights reserved

Erythrocyte surface: novel determinant of drug susceptibility in rodent malaria

Antimicrobial Agents and Chemotherapy

Aug 1, 1978

C D FitchR Chevli

PMID: 358916

DOI:

Abstract

To study the role of the erythrocyte membrane in the process of chloroquine accumulation, surface polypeptides were digested with a nonspecific protease from Streptomyces griseus. This treatment activated a saturable process of chloroquine accumulation with an affinity and a specificity...read more

Mentioned in this Paper

Plasmodium berghei
Antibiotic Resistance, Microbial
Cinchona pubescens
Alb
Sigmoid Colon
Cold Temperature
Peptide Hydrolases
Endopeptidases
Digests
Glucose, (beta-D)-Isomer

Similar Papers Found In These Feeds

Plasmodium Falciparum

Malaria remains a major cause of morbidity and mortality in the tropics, with the parasite Plasmodium falciparum responsible for the majority of the disease burden. Discover the latest research on Plasmodium falciparum.

Malaria Vaccines

Research for development of a malaria vaccine is currently underway to find an effective modality to control and eliminate the transmission of malaria. To date, no vaccine has been found to be efficacious in fighting against malaria. Here is the latest research on malaria vaccines.

Related Papers

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology

Molecular karyotypes: separating chromosomes on gels

BioEssays : News and Reviews in Molecular, Cellular and Developmental BiologyDecember 1, 1985
L M Corcoran
Life Sciences

Chloroquine accumulation by erythrocytes: a latent capability

Life SciencesJune 16, 1974
C D FitchY Gonzalez
Paper Details
References
  • References12
  • Citations18
12
  • References12
  • Citations18
12
/papers/erythrocyte-surface-novel-determinant-of-drug/358916