PMID: 8609251Mar 1, 1996Paper

Erythroderma after autologous bone marrow transplantation modified by administration of cyclosporine and interferon gamma for breast cancer

Journal of the American Academy of Dermatology
T D HornM J Kennedy

Abstract

Allogeneic graft-versus-host disease is associated with decreased rates of tumor relapse. The addition of interferon gamma to cyclosporine, given to induce graft-versus-host disease after autologous bone marrow transplantation, increases the extent of the cutaneous eruption. Our purpose was to describe the clinical and histologic cutaneous changes in 10 patients with breast cancer who received interferon gamma to potentiate graft-versus-host disease after autologous bone marrow transplantation modified by cyclosporine. Ten women receiving autologous bone marrow transplantation modified by the administration of cyclosporine and interferon gamma were observed clinically with sequential biopsy of the skin weekly and at the time of cutaneous eruptions. Erythroderma (stage 3) developed in five women after the first or second administration of interferon gamma. At least on skin biopsy specimen from 7 of the 10 women showed grade 2 changes of graft-versus-host reaction, including all patients with erythroderma. Epidermal intercellular edema was prominent in these specimens with expression of keratinocyte HLA-DR and intercellular adhesion molecule 1. Induction of keratinocyte HLA-DR and intercellular adhesion molecule 1 expression was ...Continue Reading

Citations

Oct 2, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Brian A Baldo
Aug 16, 2000·Dermatologic Clinics·M J RotheJ M Grant-Kels
Apr 2, 2005·Clinics in Dermatology·Marti Jill RotheJane M Grant-Kels
Dec 25, 2003·International Journal of Dermatology·Virendra N SehgalKabir Sardana
May 20, 1998·Journal of the National Cancer Institute·C C Gotay, M Y Muraoka
May 20, 1998·Dermatologic Clinics·R Stadler

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