Erythroid burst formation in cultures of bone marrow and peripheral blood from patients with refractory anemia

Acta Haematologica
D Amato, N R Khan

Abstract

We have studied the growth of erythroid bursts in methylcellulose cultures from bone marrow (7 cases) and peripheral blood cells (17 cases) of patients with primary acquired refractory anemias. In most cases, erythroid burst-forming units (BFU-E) were either absent or present in lower than normal numbers, and these levels remained low to absent in sequential studies. In 2 patients, circulating BFU-E were initially higher than normal, but subsequently declined to normal levels. 1 patient had low-normal numbers of circulating BFU-E initially, but these declined to zero in a later study. No clinical or routine hematological features permitted distinction between patients with initially high BFU-E and those with initially low or absent BFU-E. These findings parallel those reported for granulocyte-macrophage progenitors in refractory anemias, and support the concept that erythroid progenitor cells in these disorders are influenced by the disordered hematopoiesis.

Citations

Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·W VerbeekW Hiddemann
Nov 1, 1995·Critical Reviews in Oncology/hematology·J E Trey, I Kushner
Jan 11, 1992·Critical Reviews in Oncology/hematology·P Noël, L A Solberg
Oct 1, 1989·British Journal of Haematology·S MerchavI Tatarsky
Sep 1, 1987·International Journal of Cell Cloning·Y Yoshida
Jan 1, 1998·Hematology·D J Culligan
Jan 1, 1986·Scandinavian Journal of Haematology. Supplementum·S PartanenT Ruutu

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