Erythroid colony growth in vitro from human peripheral blood null cells: evidence for regulation by T-lymphocytes and monocytes

British Journal of Haematology
C D ReidI Chanarin

Abstract

Colony assays in methylcellulose of primitive erythroid precursors (BFU-E) were carried out from the null cell fraction of normal human peripheral blood lymphoid cells. There was little proliferation or maturation of BFU-E as assessed by both the number and the size of colonies formed, when null cells alone were cultured. Culture of null cells with up to 8 X 10(5) autologous T-lymphocytes per ml led to considerable stimulation of colony growth and maturation. Culture of null cells with peripheral blood monocytes also resulted in the indication of BFU-E growth, although the response was inferior to the seen with T-cells. Co-culture of null cells together with both T-cells and monocytes resulted in a uniformly greater response than with either alone, and this was shown to be due to a positive interaction between these two cell types.

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Citations

Jan 1, 1989·International Journal of Cell Cloning·K Pantel, A Nakeff
Aug 1, 1985·British Journal of Haematology·A NajmanG Duhamel
Nov 1, 1992·British Journal of Haematology·C D Reid
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Jan 1, 1986·Critical Reviews in Oncology/hematology·C A Sieff
Jan 1, 1985·Critical Reviews in Oncology/hematology·A M Gewirtz, R Hoffman

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