Erythromelalgia and livedo reticularis in a patient with essential thrombocythemia, acquired von Willebrand disease, and elevated anti-phospholipid antibodies.

Annals of Dermatology
Thilo Gambichler, Rebecca Matip

Abstract

Essential thrombocythemia (ET) is a clonal stem cell disease characterized by isolated thrombocytosis and thrombohemorrhagic complications. We describe an unusual case of ET primarily presenting with skin symptoms including erythromelalgia and livedo reticularis (racemosa-type). Persistent thrombocytosis, bone marrow findings, JAK2 gene mutation, and markedly decreased ristocetin-cofactor activity were consistent with the diagnosis of ET and acquired von Willebrand disease. Elevated antiphospholipid antibodies were also found. The present case highlights the complex nature and diagnostic challenge of myeloproliferative disorders such as ET, which can involve multiple organ systems and often shows a variety of microvascular complications, coagulation anomalies, and autoimmune phenomena.

References

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Citations

Jun 21, 2018·Anais Brasileiros De Dermatologia·Ana Cecilia Lamadrid-ZertucheJorge de Jesús Ocampo-Candiani
Dec 9, 2020·Thrombosis Research·Snjezana JanjetovicMinna Voigtlaender
Jan 1, 2018·Anais Brasileiros De Dermatologia·Ana Cecilia Lamadrid-ZertucheVerónica Garza-Rodríguez

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Methods Mentioned

BETA
biopsy
MDS

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