Erythromycin binding to human serum

Biochemical Pharmacology
G A DetteG Herrmann

Abstract

Erythromycin binding to human serum was measured under conditions of binding equilibrium. The binding is sensitive to pH changes, decreasing at acid pH. Over a great range of serum dilution, the bound fraction is semilogarithmically related to serum concentration. Binding is shown to be completely reversible. With increasing erythromycin concentration a specific part of binding is saturable and specifically displaceable by erythromycin is specifically bound to a single class of noninteracting binding sites with an apparent dissociation constant Kd = 5.9 microM (38 degrees C). The kinetic and thermodynamic parameters at 25 degrees are: Kd = 8.4 microM, delta H degrees = +4.4 X 10(3) cal per mole, delta G degrees = 6.9 X 10(3) cal per mole, delta S degrees = +38 e.u.

References

Feb 1, 1976·Journal of Pharmaceutical Sciences·H Zia, J C Price
Jul 1, 1973·Journal of Pharmaceutical Sciences·R C GordonW M Kirby
Mar 1, 1972·Journal of Pharmaceutical Sciences·R G Wiegand, A H Chun
May 1, 1980·The Journal of Antimicrobial Chemotherapy·G N Rolinson
Oct 8, 1962·Biochimica Et Biophysica Acta·J P HUMMEL, W J DREYER
Jul 1, 1965·The Journal of Thoracic and Cardiovascular Surgery·P HALLOWELLM B LAVER
Aug 14, 1952·The New England Journal of Medicine·T H HAIGHT, M FINLAND

Citations

Oct 8, 1999·European Journal of Drug Metabolism and Pharmacokinetics·M AhmadN I Bukhari
May 5, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Karen Rowland YeoGeoffrey T Tucker
Dec 1, 1989·Journal of Pharmaceutical Sciences·M P FournetJ P Tillement

Related Concepts

Serum Proteins
Ilotycin
Hydrogen-Ion Concentration
Plasma Protein Binding Capacity

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