Erythromycin lacks colon prokinetic effect in children with functional gastrointestinal disorders: a retrospective study.

BMC Gastroenterology
Narayanan VenkatasubramaniManu R Sood

Abstract

Motilin, a peptide hormone has a direct excitatory effect on circular smooth muscle strips derived from the human colon. Reduced plasma motilin concentration has been reported in adults with chronic constipation. Erythromycin, a non-peptide motilin receptor agonist, induces phase 3 of the migrating motor complex (MMC) in the antro-duodenum and also reduces oro-cecal transit time. A pediatric study has reported an improvement in clinical symptoms of constipation following erythromycin administration, but the effect on colon motility in children has not been formally evaluated. We used colon manometry to study the effect of intravenous erythromycin lactobionate at 1 mg/kg on colon motility in ten children. We selected patients with normal antroduodenal and colon manometry studies that were performed simultaneously. All studies were performed for clinically indicated reasons. We quantified the effect of erythromycin on colon contraction by calculating the area under the curve (AUC). The mean (SE of mean) AUC in the colon during the fasting, post-erythromycin and postprandial phases of the study was 2.1 mmHg/sec (0.35), 0.99 mmHg/sec (0.17) and 3.05 mmHg/sec (0.70) respectively. The AUC following erythromycin was significantly less...Continue Reading

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Citations

Sep 3, 2013·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Seyed Mohsen DehghaniHeidar Ali Kaffashan
Dec 30, 2014·BioMed Research International·Mei LiuZhongping Duan
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May 12, 2009·Pharmacology & Therapeutics·Betty De SmetInge Depoortere
May 1, 2016·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Sadegh JafarnejadKurosh Djafarian
Sep 30, 2009·Current Opinion in Gastroenterology·Eamonn M M Quigley
Jan 25, 2019·Nature Reviews. Endocrinology·Eveline DelooseJan Tack

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Methods Mentioned

BETA
motility studies
biopsies

Software Mentioned

SPSS

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