Erythropoiesis-stimulating Agents and Anemia in Patients with Non-dialytic Chronic Kidney Disease

Journal of Korean Medical Science
Sun Moon KimHye-Young Kim

Abstract

Anemia is common in patients with advanced chronic kidney disease (CKD). Though erythropoiesis-stimulating agents (ESAs) have been strongly endorsed in guidelines, it is of particular financial interest. Recently, the reimbursement of ESAs in non-dialytic patients was started by the Korean National Health Insurance System. Thus, we investigated the impact of the reimbursement of ESAs on the anemia care in non-dialytic CKD patients. Medical records of patients with advanced CKD (estimated GFR <30 mL/min/1.73 m(2)) were reviewed. Use of ESAs, blood transfusion, and hemoglobin concentrations were analyzed from one year prior to reimbursement to three years following. We used multivariable modified Poisson regression to estimate the utilization prevalence ratio (PRs). A total of 1,791 medical records were analyzed. The proportion of patients receiving ESAs increased from 14.8% before reimbursement to a peak 33.6% in 1 yr after reimbursement; thereafter, ESA use decreased to 22.4% in 3 yr after reimbursement (compared with baseline; PR, 2.19 [95% CI, 1.40-3.42]). In patients with Hb <10 g/dL, the proportion of receiving ESAs increased from 32.1% before reimbursement to 66.7% in 3 yr after reimbursement (compared with baseline; PR, 2...Continue Reading

References

Jul 1, 1985·Kidney International·J W Eschbach, J W Adamson
Oct 25, 2002·Journal of the American Society of Nephrology : JASN·Chi-Yuan HsuGary C Curhan
Dec 14, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fernando ValderrábanoJean-Pierre Wauters
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Walter H HörlUNKNOWN Predialysis Survey on Anemia Management
Jun 24, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ronald L PisoniFriedrich K Port
Nov 17, 2006·The New England Journal of Medicine·Tilman B DrüekeUNKNOWN CREATE Investigators
Nov 17, 2006·The New England Journal of Medicine·Ajay K SinghUNKNOWN CHOIR Investigators
Aug 28, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN KDOQI
Oct 1, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hassan N IbrahimAllan J Collins
May 20, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hassan N IbrahimDavid T Gilbertson
Nov 3, 2009·The New England Journal of Medicine·Marc A PfefferUNKNOWN TREAT Investigators
Feb 8, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Karminder S GillBrian D Bradbury
Mar 5, 2014·JAMA Internal Medicine·Wolfgang C WinkelmayerGlenn M Chertow
Oct 21, 2015·Kidney Research and Clinical Practice·Mi Yeon JungYoung Joo Kwon

❮ Previous
Next ❯

Citations

Jul 1, 2016·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Mohammed Abdulrahman S AlosayfirHussain Gadelkarim Ahmed

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Marie EvansJuan-Jesus Carrero
Clinical Journal of the American Society of Nephrology : CJASN
Neil C BoudvilleAdeera Levin
Clinical Journal of the American Society of Nephrology : CJASN
Elizabeth V LawlerDavid R Gagnon
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Ioannis KoulouridisBertrand L Jaber
© 2022 Meta ULC. All rights reserved